| 1 | Sat 14 Aug 2021 | 80-0 v Tranmere RoversPort Vale 0-0 Tranmere Rovers |
| 2 | Tue 17 Aug 2021 | 80-0 v Carlisle UnitedPort Vale 0-0 Carlisle United |
| 3 | Sat 21 Aug 2021 | 81-1 v StevenageStevenage 1-1 Port Vale |
| 4 | Sat 28 Aug 2021 | 82-0 v Forest Green RoversForest Green Rovers 0-2 Port Vale |
| 5 | Sat 4 Sep 2021 | 82-3 v RochdalePort Vale 2-3 Rochdale |
| 6 | Sat 11 Sep 2021 | 82-1 v Swindon TownSwindon Town 1-2 Port Vale |
| 7 | Sat 18 Sep 2021 | 82-0 v Harrogate TownPort Vale 2-0 Harrogate Town |
| 8 | Sat 25 Sep 2021 | 81-0 v Scunthorpe UnitedScunthorpe United 0-1 Port Vale |
| 9 | Sat 2 Oct 2021 | 83-2 v Leyton OrientPort Vale 3-2 Leyton Orient |
| 10 | Sat 9 Oct 2021 | 83-4 v Sutton UnitedSutton United 4-3 Port Vale |
| 11 | Sat 16 Oct 2021 | 83-1 v BarrowPort Vale 3-1 Barrow |
| 12 | Tue 19 Oct 2021 | 81-1 v Mansfield TownMansfield Town 1-1 Port Vale |
| 13 | Sat 30 Oct 2021 | 8 4-1 v Crawley TownCrawley Town 1-4 Port Vale |
| 14 | Sat 13 Nov 2021 | 81-1 v Bradford CityPort Vale 1-1 Bradford City |
| 15 | Sat 20 Nov 2021 | 8 2-3 v Oldham AthleticOldham Athletic 3-2 Port Vale |
| 16 | Tue 23 Nov 2021 | 80-1 v WalsallPort Vale 0-1 Walsall |
| 17 | Sat 27 Nov 2021 | 82-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United |
| 18 | Tue 7 Dec 2021 | 82-1 v Bristol RoversBristol Rovers 1-2 Port Vale |
| 19 | Sat 11 Dec 2021 | 81-2 v Newport CountyNewport County 2-1 Port Vale |
| 20 | Sat 15 Jan 2022 | 81-3 v Swindon TownPort Vale 1-3 Swindon Town |
| 21 | Tue 18 Jan 2022 | 80-1 v Salford CityPort Vale 0-1 Salford City |
| 22 | Sat 22 Jan 2022 | 8 0-0 v Leyton OrientLeyton Orient 0-0 Port Vale |
| 23 | Sat 29 Jan 2022 | 81-0 v Scunthorpe UnitedPort Vale 1-0 Scunthorpe United |
| 24 | Tue 1 Feb 2022 | 81-1 v Forest Green RoversPort Vale 1-1 Forest Green Rovers |
| 25 | Tue 8 Feb 2022 | 83-1 v Carlisle UnitedCarlisle United 1-3 Port Vale |
| 26 | Sat 12 Feb 2022 | 80-0 v Northampton TownPort Vale 0-0 Northampton Town |
| 27 | Sat 19 Feb 2022 | 81-1 v Tranmere RoversTranmere Rovers 1-1 Port Vale |
| 28 | Tue 22 Feb 2022 | 81-1 v RochdaleRochdale 1-1 Port Vale |
| 29 | Sat 26 Feb 2022 | 82-0 v StevenagePort Vale 2-0 Stevenage |
| 30 | Tue 1 Mar 2022 | 81-1 v Harrogate TownHarrogate Town 1-1 Port Vale |
| 31 | Sat 5 Mar 2022 | 80-1 v Colchester UnitedColchester United 1-0 Port Vale |
| 32 | Sat 12 Mar 2022 | 84-1 v Crawley TownPort Vale 4-1 Crawley Town |
| 33 | Tue 15 Mar 2022 | 83-1 v Mansfield TownPort Vale 3-1 Mansfield Town |
| 34 | Sat 19 Mar 2022 | 82-1 v Bradford CityBradford City 1-2 Port Vale |
| 35 | Tue 22 Mar 2022 | 80-0 v Exeter CityPort Vale 0-0 Exeter City |
| 36 | Sat 26 Mar 2022 | 82-0 v Sutton UnitedPort Vale 2-0 Sutton United |
| 37 | Tue 5 Apr 2022 | 81-0 v Salford CitySalford City 0-1 Port Vale |
| 38 | Sat 9 Apr 2022 | 8 3-2 v Oldham AthleticPort Vale 3-2 Oldham Athletic |
| 39 | Fri 15 Apr 2022 | 81-0 v Hartlepool UnitedHartlepool United 0-1 Port Vale |
| 40 | Mon 18 Apr 2022 | 81-3 v Bristol RoversPort Vale 1-3 Bristol Rovers |
| 41 | Sat 23 Apr 2022 | 80-2 v WalsallWalsall 2-0 Port Vale |
| 42 | Mon 2 May 2022 | 81-2 v Newport CountyPort Vale 1-2 Newport County |
| 43 | Sat 7 May 2022 | 81-0 v Exeter CityExeter City 0-1 Port Vale |
| 44 | Sun 15 May 2022 | 81-2 v Swindon TownSwindon Town 2-1 Port Vale |
| 45 | Thu 19 May 2022 | 81-0 v Swindon TownPort Vale 1-0 Swindon Town |
| 46 | Sat 28 May 2022 | 83-0 v Mansfield TownMansfield Town 0-3 Port Vale |
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