| 1 | Sat 14 Aug 2021 | 40-0 v Tranmere RoversPort Vale 0-0 Tranmere Rovers |
| 2 | Tue 17 Aug 2021 | 40-0 v Carlisle UnitedPort Vale 0-0 Carlisle United |
| 3 | Sat 21 Aug 2021 | 4 1-1 v StevenageStevenage 1-1 Port Vale |
| 4 | Sat 28 Aug 2021 | 4 2-0 v Forest Green RoversForest Green Rovers 0-2 Port Vale |
| 5 | Sat 4 Sep 2021 | 42-3 v RochdalePort Vale 2-3 Rochdale |
| 6 | Sat 27 Nov 2021 | 4 2-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United |
| 7 | Tue 7 Dec 2021 | 42-1 v Bristol RoversBristol Rovers 1-2 Port Vale |
| 8 | Sat 11 Dec 2021 | 4 1-2 v Newport CountyNewport County 2-1 Port Vale |
| 9 | Tue 18 Jan 2022 | 4 0-1 v Salford CityPort Vale 0-1 Salford City |
| 10 | Sat 22 Jan 2022 | 4 0-0 v Leyton OrientLeyton Orient 0-0 Port Vale |
| 11 | Sat 29 Jan 2022 | 41-0 v Scunthorpe UnitedPort Vale 1-0 Scunthorpe United |
| 12 | Tue 1 Feb 2022 | 41-1 v Forest Green RoversPort Vale 1-1 Forest Green Rovers |
| 13 | Tue 8 Feb 2022 | 43-1 v Carlisle UnitedCarlisle United 1-3 Port Vale |
| 14 | Sat 12 Feb 2022 | 40-0 v Northampton TownPort Vale 0-0 Northampton Town |
| 15 | Sat 19 Feb 2022 | 41-1 v Tranmere RoversTranmere Rovers 1-1 Port Vale |
| 16 | Tue 22 Feb 2022 | 41-1 v RochdaleRochdale 1-1 Port Vale |
| 17 | Sat 26 Feb 2022 | 4 2-0 v StevenagePort Vale 2-0 Stevenage |
| 18 | Tue 1 Mar 2022 | 41-1 v Harrogate TownHarrogate Town 1-1 Port Vale |
| 19 | Sat 12 Mar 2022 | 44-1 v Crawley TownPort Vale 4-1 Crawley Town |
| 20 | Tue 15 Mar 2022 | 43-1 v Mansfield TownPort Vale 3-1 Mansfield Town |
| 21 | Sat 19 Mar 2022 | 4 2-1 v Bradford CityBradford City 1-2 Port Vale |
| 22 | Tue 22 Mar 2022 | 40-0 v Exeter CityPort Vale 0-0 Exeter City |
| 23 | Sat 26 Mar 2022 | 4 2-0 v Sutton UnitedPort Vale 2-0 Sutton United |
| 24 | Sat 2 Apr 2022 | 4 2-1 v BarrowBarrow 1-2 Port Vale |
| 25 | Tue 5 Apr 2022 | 4 1-0 v Salford CitySalford City 0-1 Port Vale |
| 26 | Sat 9 Apr 2022 | 43-2 v Oldham AthleticPort Vale 3-2 Oldham Athletic |
| 27 | Fri 15 Apr 2022 | 41-0 v Hartlepool UnitedHartlepool United 0-1 Port Vale |
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