| 1 | Sat 11 Sep 2021 | 22-1 v Swindon TownSwindon Town 1-2 Port Vale |
| 2 | Sat 18 Sep 2021 | 22-0 v Harrogate TownPort Vale 2-0 Harrogate Town |
| 3 | Sat 25 Sep 2021 | 21-0 v Scunthorpe UnitedScunthorpe United 0-1 Port Vale |
| 4 | Sat 2 Oct 2021 | 23-2 v Leyton OrientPort Vale 3-2 Leyton Orient |
| 5 | Sat 9 Oct 2021 | 2 3-4 v Sutton UnitedSutton United 4-3 Port Vale |
| 6 | Sat 16 Oct 2021 | 23-1 v BarrowPort Vale 3-1 Barrow |
| 7 | Tue 19 Oct 2021 | 21-1 v Mansfield TownMansfield Town 1-1 Port Vale |
| 8 | Sat 23 Oct 2021 | 2 3-0 v Colchester UnitedPort Vale 3-0 Colchester United |
| 9 | Sat 30 Oct 2021 | 24-1 v Crawley TownCrawley Town 1-4 Port Vale |
| 10 | Sat 13 Nov 2021 | 21-1 v Bradford CityPort Vale 1-1 Bradford City |
| 11 | Sat 20 Nov 2021 | 22-3 v Oldham AthleticOldham Athletic 3-2 Port Vale |
| 12 | Tue 23 Nov 2021 | 2 0-1 v WalsallPort Vale 0-1 Walsall |
| 13 | Sat 27 Nov 2021 | 2 2-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United |
| 14 | Tue 7 Dec 2021 | 22-1 v Bristol RoversBristol Rovers 1-2 Port Vale |
| 15 | Sat 11 Dec 2021 | 2 1-2 v Newport CountyNewport County 2-1 Port Vale |
| 16 | Tue 18 Jan 2022 | 2 0-1 v Salford CityPort Vale 0-1 Salford City |
| 17 | Sat 22 Jan 2022 | 20-0 v Leyton OrientLeyton Orient 0-0 Port Vale |
| 18 | Sat 19 Feb 2022 | 21-1 v Tranmere RoversTranmere Rovers 1-1 Port Vale |
| 19 | Tue 22 Feb 2022 | 21-1 v RochdaleRochdale 1-1 Port Vale |
| 20 | Sat 26 Feb 2022 | 22-0 v StevenagePort Vale 2-0 Stevenage |
| 21 | Tue 1 Mar 2022 | 21-1 v Harrogate TownHarrogate Town 1-1 Port Vale |
| 22 | Mon 2 May 2022 | 21-2 v Newport CountyPort Vale 1-2 Newport County |
| 23 | Sat 7 May 2022 | 21-0 v Exeter CityExeter City 0-1 Port Vale |
| 24 | Sun 15 May 2022 | 21-2 v Swindon TownSwindon Town 2-1 Port Vale |
| 25 | Thu 19 May 2022 | 21-0 v Swindon TownPort Vale 1-0 Swindon Town |
| 26 | Sat 28 May 2022 | 23-0 v Mansfield TownMansfield Town 0-3 Port Vale |
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