| 1 | Sat 7 Aug 2021 | 21-0 v WalsallTranmere Rovers 1-0 Walsall |
| 2 | Sat 14 Aug 2021 | 20-0 v Port ValePort Vale 0-0 Tranmere Rovers |
| 3 | Tue 17 Aug 2021 | 20-0 v Swindon TownSwindon Town 0-0 Tranmere Rovers |
| 4 | Sat 21 Aug 2021 | 20-1 v Newport CountyTranmere Rovers 0-1 Newport County |
| 5 | Sat 28 Aug 2021 | 20-1 v Scunthorpe UnitedScunthorpe United 1-0 Tranmere Rovers |
| 6 | Sat 4 Sep 2021 | 21-0 v Hartlepool UnitedTranmere Rovers 1-0 Hartlepool United |
| 7 | Sat 11 Sep 2021 | 20-1 v RochdaleRochdale 1-0 Tranmere Rovers |
| 8 | Sat 18 Sep 2021 | 22-0 v Salford CityTranmere Rovers 2-0 Salford City |
| 9 | Sat 25 Sep 2021 | 20-0 v Forest Green RoversForest Green Rovers 0-0 Tranmere Rovers |
| 10 | Sat 2 Oct 2021 | 2 2-1 v Crawley TownTranmere Rovers 2-1 Crawley Town |
| 11 | Fri 8 Oct 2021 | 22-0 v Colchester UnitedTranmere Rovers 2-0 Colchester United |
| 12 | Sat 16 Oct 2021 | 21-0 v Carlisle UnitedCarlisle United 0-1 Tranmere Rovers |
| 13 | Tue 19 Oct 2021 | 2 2-2 v Harrogate TownHarrogate Town 2-2 Tranmere Rovers |
| 14 | Sat 23 Oct 2021 | 20-2 v Northampton TownTranmere Rovers 0-2 Northampton Town |
| 15 | Sat 30 Oct 2021 | 20-2 v Mansfield TownMansfield Town 2-0 Tranmere Rovers |
| 16 | Sat 13 Nov 2021 | 20-1 v Sutton UnitedTranmere Rovers 0-1 Sutton United |
| 17 | Sat 20 Nov 2021 | 22-2 v Bristol RoversBristol Rovers 2-2 Tranmere Rovers |
| 18 | Tue 23 Nov 2021 | 22-1 v Bradford CityTranmere Rovers 2-1 Bradford City |
| 19 | Tue 7 Dec 2021 | 21-0 v Oldham AthleticOldham Athletic 0-1 Tranmere Rovers |
| 20 | Sat 11 Dec 2021 | 21-0 v Exeter CityExeter City 0-1 Tranmere Rovers |
| 21 | Sat 18 Dec 2021 | 21-0 v Leyton OrientTranmere Rovers 1-0 Leyton Orient |
| 22 | Sat 8 Jan 2022 | 24-0 v Scunthorpe UnitedTranmere Rovers 4-0 Scunthorpe United |
| 23 | Tue 11 Jan 2022 | 21-1 v Salford CitySalford City 1-1 Tranmere Rovers |
| 24 | Sat 15 Jan 2022 | 22-0 v RochdaleTranmere Rovers 2-0 Rochdale |
| 25 | Sat 22 Jan 2022 | 21-0 v Crawley TownCrawley Town 0-1 Tranmere Rovers |
| 26 | Sat 29 Jan 2022 | 20-4 v Forest Green RoversTranmere Rovers 0-4 Forest Green Rovers |
| 27 | Tue 1 Feb 2022 | 21-0 v StevenageTranmere Rovers 1-0 Stevenage |
| 28 | Sat 5 Feb 2022 | 2 1-1 v BarrowBarrow 1-1 Tranmere Rovers |
| 29 | Tue 8 Feb 2022 | 23-0 v Swindon TownTranmere Rovers 3-0 Swindon Town |
| 30 | Sat 12 Feb 2022 | 20-1 v WalsallWalsall 1-0 Tranmere Rovers |
| 31 | Tue 15 Feb 2022 | 20-1 v Hartlepool UnitedHartlepool United 1-0 Tranmere Rovers |
| 32 | Sat 19 Feb 2022 | 21-1 v Port ValeTranmere Rovers 1-1 Port Vale |
| 33 | Sat 26 Feb 2022 | 22-4 v Newport CountyNewport County 4-2 Tranmere Rovers |
| 34 | Sat 5 Mar 2022 | 22-3 v Northampton TownNorthampton Town 3-2 Tranmere Rovers |
| 35 | Fri 11 Mar 2022 | 23-2 v Mansfield TownTranmere Rovers 3-2 Mansfield Town |
| 36 | Tue 15 Mar 2022 | 22-0 v Harrogate TownTranmere Rovers 2-0 Harrogate Town |
| 37 | Sat 19 Mar 2022 | 21-1 v Sutton UnitedSutton United 1-1 Tranmere Rovers |
| 38 | Sat 26 Mar 2022 | 20-1 v Colchester UnitedColchester United 1-0 Tranmere Rovers |
| 39 | Sat 2 Apr 2022 | 2 2-2 v Carlisle UnitedTranmere Rovers 2-2 Carlisle United |
| 40 | Sat 9 Apr 2022 | 21-1 v Bristol RoversTranmere Rovers 1-1 Bristol Rovers |
| 41 | Fri 15 Apr 2022 | 21-1 v Bradford CityBradford City 1-1 Tranmere Rovers |
| 42 | Mon 18 Apr 2022 | 22-0 v Exeter CityTranmere Rovers 2-0 Exeter City |
| 43 | Sat 23 Apr 2022 | 20-2 v StevenageStevenage 2-0 Tranmere Rovers |
| 44 | Sat 30 Apr 2022 | 22-0 v Oldham AthleticTranmere Rovers 2-0 Oldham Athletic |
| 45 | Sat 7 May 2022 | 21-0 v Leyton OrientLeyton Orient 0-1 Tranmere Rovers |
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