| 1 | Sat 14 Aug 2021 | 10-0 v Tranmere RoversPort Vale 0-0 Tranmere Rovers |
| 2 | Tue 17 Aug 2021 | 10-0 v Carlisle UnitedPort Vale 0-0 Carlisle United |
| 3 | Sat 21 Aug 2021 | 11-1 v StevenageStevenage 1-1 Port Vale |
| 4 | Sat 28 Aug 2021 | 12-0 v Forest Green RoversForest Green Rovers 0-2 Port Vale |
| 5 | Sat 4 Sep 2021 | 12-3 v RochdalePort Vale 2-3 Rochdale |
| 6 | Sat 11 Sep 2021 | 12-1 v Swindon TownSwindon Town 1-2 Port Vale |
| 7 | Sat 18 Sep 2021 | 12-0 v Harrogate TownPort Vale 2-0 Harrogate Town |
| 8 | Sat 25 Sep 2021 | 11-0 v Scunthorpe UnitedScunthorpe United 0-1 Port Vale |
| 9 | Sat 2 Oct 2021 | 13-2 v Leyton OrientPort Vale 3-2 Leyton Orient |
| 10 | Sat 9 Oct 2021 | 13-4 v Sutton UnitedSutton United 4-3 Port Vale |
| 11 | Sat 16 Oct 2021 | 13-1 v BarrowPort Vale 3-1 Barrow |
| 12 | Tue 19 Oct 2021 | 11-1 v Mansfield TownMansfield Town 1-1 Port Vale |
| 13 | Sat 23 Oct 2021 | 13-0 v Colchester UnitedPort Vale 3-0 Colchester United |
| 14 | Sat 30 Oct 2021 | 14-1 v Crawley TownCrawley Town 1-4 Port Vale |
| 15 | Sat 13 Nov 2021 | 11-1 v Bradford CityPort Vale 1-1 Bradford City |
| 16 | Sat 20 Nov 2021 | 12-3 v Oldham AthleticOldham Athletic 3-2 Port Vale |
| 17 | Tue 23 Nov 2021 | 10-1 v WalsallPort Vale 0-1 Walsall |
| 18 | Sat 27 Nov 2021 | 12-0 v Hartlepool UnitedPort Vale 2-0 Hartlepool United |
| 19 | Sat 11 Dec 2021 | 1 1-2 v Newport CountyNewport County 2-1 Port Vale |
| 20 | Sat 15 Jan 2022 | 1 1-3 v Swindon TownPort Vale 1-3 Swindon Town |
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