| 1 | Fri 4 Aug | 232-1 v Sheffield WednesdaySheffield Wednesday 1-2 Southampton | Sky Bet Championship |
| 2 | Sat 12 Aug | 23 4-4 v Norwich CitySouthampton 4-4 Norwich City | Sky Bet Championship |
| 3 | Sat 19 Aug | 232-1 v Plymouth ArgylePlymouth Argyle 1-2 Southampton | Sky Bet Championship |
| 4 | Sat 26 Aug | 232-1 v Queens Park RangersSouthampton 2-1 Queens Park Rangers | Sky Bet Championship |
| 5 | Sat 2 Sep | 230-5 v SunderlandSunderland 5-0 Southampton | Sky Bet Championship |
| 6 | Fri 15 Sep | 231-4 v Leicester CitySouthampton 1-4 Leicester City | Sky Bet Championship |
| 7 | Tue 19 Sep | 230-1 v Ipswich TownSouthampton 0-1 Ipswich Town | Sky Bet Championship |
| 8 | Sat 23 Sep | 231-2 v MiddlesbroughMiddlesbrough 2-1 Southampton | Sky Bet Championship |
| 9 | Sat 7 Oct | 231-1 v Rotherham UnitedSouthampton 1-1 Rotherham United | Sky Bet Championship |
| 10 | Sat 21 Oct | 232-1 v Hull CityHull City 1-2 Southampton | Sky Bet Championship |
| 11 | Wed 25 Oct | 232-2 v Preston North EndPreston North End 2-2 Southampton | Sky Bet Championship |
| 12 | Sat 28 Oct | 233-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 13 | Sat 25 Nov | 231-1 v Huddersfield TownHuddersfield Town 1-1 Southampton | Sky Bet Championship |
| 14 | Wed 13 Dec | 231-1 v Coventry CityCoventry City 1-1 Southampton | Sky Bet Championship |
| 15 | Sat 16 Dec | 234-0 v Blackburn RoversSouthampton 4-0 Blackburn Rovers | Sky Bet Championship |
| 16 | Sat 23 Dec | 231-0 v Queens Park RangersQueens Park Rangers 0-1 Southampton | Sky Bet Championship |
| 17 | Tue 26 Dec | 235-0 v Swansea CitySouthampton 5-0 Swansea City | Sky Bet Championship |
| 18 | Fri 29 Dec | 232-1 v Plymouth ArgyleSouthampton 2-1 Plymouth Argyle | Sky Bet Championship |
| 19 | Mon 1 Jan | 231-1 v Norwich CityNorwich City 1-1 Southampton | Sky Bet Championship |
| 20 | Tue 6 Feb | 23 3-0 v WatfordSouthampton 3-0 Watford | Emirates FA Cup Fourth Round Replay |
| 21 | Sat 10 Feb | 235-3 v Huddersfield TownSouthampton 5-3 Huddersfield Town | Sky Bet Championship |
| 22 | Tue 13 Feb | 231-3 v Bristol CityBristol City 3-1 Southampton | Sky Bet Championship |
| 23 | Fri 16 Feb | 232-0 v West Bromwich AlbionWest Bromwich Albion 0-2 Southampton | Sky Bet Championship |
| 24 | Tue 20 Feb | 231-2 v Hull CitySouthampton 1-2 Hull City | Sky Bet Championship |
| 25 | Sat 24 Feb | 23 1-2 v MillwallSouthampton 1-2 Millwall | Sky Bet Championship |
| 26 | Wed 28 Feb | 230-3 v LiverpoolLiverpool 3-0 Southampton | Emirates FA Cup Fifth Round |
| 27 | Sat 2 Mar | 234-3 v Birmingham CityBirmingham City 3-4 Southampton | Sky Bet Championship |
| 28 | Fri 29 Mar | 231-1 v MiddlesbroughSouthampton 1-1 Middlesbrough | Sky Bet Championship |
| 29 | Mon 1 Apr | 232-3 v Ipswich TownIpswich Town 3-2 Southampton | Sky Bet Championship |
| 30 | Sat 6 Apr | 230-0 v Blackburn RoversBlackburn Rovers 0-0 Southampton | Sky Bet Championship |
| 31 | Tue 16 Apr | 233-0 v Preston North EndSouthampton 3-0 Preston North End | Sky Bet Championship |
| 32 | Sat 20 Apr | 231-2 v Cardiff CityCardiff City 2-1 Southampton | Sky Bet Championship |
| 33 | Tue 23 Apr | 230-5 v Leicester CityLeicester City 5-0 Southampton | Sky Bet Championship |
| 34 | Sat 27 Apr | 230-1 v Stoke CitySouthampton 0-1 Stoke City | Sky Bet Championship |
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