| 1 | Fri 4 Aug | 72-1 v Sheffield WednesdaySheffield Wednesday 1-2 Southampton | Sky Bet Championship |
| 2 | Sat 19 Aug | 72-1 v Plymouth ArgylePlymouth Argyle 1-2 Southampton | Sky Bet Championship |
| 3 | Sat 26 Aug | 72-1 v Queens Park RangersSouthampton 2-1 Queens Park Rangers | Sky Bet Championship |
| 4 | Sat 2 Sep | 70-5 v SunderlandSunderland 5-0 Southampton | Sky Bet Championship |
| 5 | Fri 15 Sep | 71-4 v Leicester CitySouthampton 1-4 Leicester City | Sky Bet Championship |
| 6 | Tue 19 Sep | 70-1 v Ipswich TownSouthampton 0-1 Ipswich Town | Sky Bet Championship |
| 7 | Sat 23 Sep | 71-2 v MiddlesbroughMiddlesbrough 2-1 Southampton | Sky Bet Championship |
| 8 | Sat 30 Sep | 73-1 v Leeds UnitedSouthampton 3-1 Leeds United | Sky Bet Championship |
| 9 | Tue 3 Oct | 71-0 v Stoke CityStoke City 0-1 Southampton | Sky Bet Championship |
| 10 | Sat 7 Oct | 71-1 v Rotherham UnitedSouthampton 1-1 Rotherham United | Sky Bet Championship |
| 11 | Fri 13 Oct | 2-2 v Saudi ArabiaSaudi Arabia 2-2 Nigeria | International Friendly |
| 12 | Mon 16 Oct | 103-2 v MozambiqueMozambique 2-3 Nigeria | International Friendly |
| 13 | Sat 28 Oct | 73-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 14 | Wed 29 Nov | 71-0 v Bristol CitySouthampton 1-0 Bristol City | Sky Bet Championship |
| 15 | Sat 2 Dec | 72-0 v Cardiff CitySouthampton 2-0 Cardiff City | Sky Bet Championship |
| 16 | Sat 9 Dec | 71-1 v WatfordWatford 1-1 Southampton | Sky Bet Championship |
| 17 | Wed 13 Dec | 7 1-1 v Coventry CityCoventry City 1-1 Southampton | Sky Bet Championship |
| 18 | Sat 16 Dec | 7 4-0 v Blackburn RoversSouthampton 4-0 Blackburn Rovers | Sky Bet Championship |
| 19 | Sat 23 Dec | 7 1-0 v Queens Park RangersQueens Park Rangers 0-1 Southampton | Sky Bet Championship |
| 20 | Tue 26 Dec | 7 5-0 v Swansea CitySouthampton 5-0 Swansea City | Sky Bet Championship |
| 21 | Fri 29 Dec | 72-1 v Plymouth ArgyleSouthampton 2-1 Plymouth Argyle | Sky Bet Championship |
| 22 | Mon 1 Jan | 71-1 v Norwich CityNorwich City 1-1 Southampton | Sky Bet Championship |
| 23 | Sun 14 Jan | 101-1 v Equatorial GuineaNigeria 1-1 Equatorial Guinea | Africa Cup of Nations Group A |
| 24 | Mon 22 Jan | 101-0 v Guinea-BissauGuinea-Bissau 0-1 Nigeria | Africa Cup of Nations Group A |
| 25 | Fri 2 Feb | 101-0 v AngolaNigeria 1-0 Angola | Africa Cup of Nations Quarter Final |
| 26 | Wed 7 Feb | 101-1 v South AfricaNigeria 1-1 South Africa | Africa Cup of Nations Semi Final |
| 27 | Sun 11 Feb | 101-2 v Côte d'IvoireNigeria 1-2 Côte d'Ivoire | Africa Cup of Nations Final |
| 28 | Fri 16 Feb | 72-0 v West Bromwich AlbionWest Bromwich Albion 0-2 Southampton | Sky Bet Championship |
| 29 | Tue 20 Feb | 71-2 v Hull CitySouthampton 1-2 Hull City | Sky Bet Championship |
| 30 | Sat 24 Feb | 71-2 v MillwallSouthampton 1-2 Millwall | Sky Bet Championship |
| 31 | Wed 28 Feb | 70-3 v LiverpoolLiverpool 3-0 Southampton | Emirates FA Cup Fifth Round |
| 32 | Sat 2 Mar | 74-3 v Birmingham CityBirmingham City 3-4 Southampton | Sky Bet Championship |
| 33 | Sat 9 Mar | 7 4-2 v SunderlandSouthampton 4-2 Sunderland | Sky Bet Championship |
| 34 | Fri 29 Mar | 71-1 v MiddlesbroughSouthampton 1-1 Middlesbrough | Sky Bet Championship |
| 35 | Mon 1 Apr | 72-3 v Ipswich TownIpswich Town 3-2 Southampton | Sky Bet Championship |
| 36 | Sat 6 Apr | 70-0 v Blackburn RoversBlackburn Rovers 0-0 Southampton | Sky Bet Championship |
| 37 | Tue 9 Apr | 72-1 v Coventry CitySouthampton 2-1 Coventry City | Sky Bet Championship |
| 38 | Sat 13 Apr | 73-2 v WatfordSouthampton 3-2 Watford | Sky Bet Championship |
| 39 | Tue 16 Apr | 73-0 v Preston North EndSouthampton 3-0 Preston North End | Sky Bet Championship |
| 40 | Sat 20 Apr | 71-2 v Cardiff CityCardiff City 2-1 Southampton | Sky Bet Championship |
| 41 | Tue 23 Apr | 70-5 v Leicester CityLeicester City 5-0 Southampton | Sky Bet Championship |
| 42 | Sat 27 Apr | 70-1 v Stoke CitySouthampton 0-1 Stoke City | Sky Bet Championship |
| 43 | Sat 4 May | 72-1 v Leeds UnitedLeeds United 1-2 Southampton | Sky Bet Championship |
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