| 1 | 7/8/2021 | 81-1 v Salford CitySalford City 1-1 Leyton Orient | Sky Bet League Two |
| 2 | 11/8/2021 | 81-1 v Queens Park RangersLeyton Orient 1-1 Queens Park Rangers | Carabao Cup First Round |
| 3 | 14/8/2021 | 83-0 v Exeter CityLeyton Orient 3-0 Exeter City | Sky Bet League Two |
| 4 | 21/8/2021 | 8 1-1 v Carlisle UnitedCarlisle United 1-1 Leyton Orient | Sky Bet League Two |
| 5 | 24/8/2021 | 80-2 v Harrogate TownLeyton Orient 0-2 Harrogate Town | Sky Bet League Two |
| 6 | 28/8/2021 | 82-0 v Bradford CityLeyton Orient 2-0 Bradford City | Sky Bet League Two |
| 7 | 4/9/2021 | 82-2 v Newport CountyNewport County 2-2 Leyton Orient | Sky Bet League Two |
| 8 | 11/9/2021 | 84-0 v Oldham AthleticLeyton Orient 4-0 Oldham Athletic | Sky Bet League Two |
| 9 | 18/9/2021 | 8 3-1 v Bristol RoversBristol Rovers 1-3 Leyton Orient | Sky Bet League Two |
| 10 | 25/9/2021 | 80-0 v Mansfield TownLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 11 | 2/10/2021 | 82-3 v Port ValePort Vale 3-2 Leyton Orient | Sky Bet League Two |
| 12 | 5/10/2021 | 84-0 v Crawley TownCrawley Town 0-4 Leyton Orient | Checkatrade Trophy |
| 13 | 9/10/2021 | 81-1 v BarrowBarrow 1-1 Leyton Orient | Sky Bet League Two |
| 14 | 16/10/2021 | 80-0 v WalsallLeyton Orient 0-0 Walsall | Sky Bet League Two |
| 15 | 19/10/2021 | 81-1 v Forest Green RoversLeyton Orient 1-1 Forest Green Rovers | Sky Bet League Two |
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