| 1 | Sun 3 Sep | 61-0 v MontpellierLille 1-0 Montpellier | French Ligue 1 |
| 2 | Sun 8 Oct | 61-1 v LensLens 1-1 Lille | French Ligue 1 |
| 3 | Sun 22 Oct | 61-0 v BrestLille 1-0 Brest | French Ligue 1 |
| 4 | Thu 26 Oct | 6 2-1 v Slovan BratislavaLille 2-1 Slovan Bratislava | UEFA Europa Conference League |
| 5 | Sun 29 Oct | 62-0 v MonacoLille 2-0 Monaco | French Ligue 1 |
| 6 | Sat 4 Nov | 6 0-0 v MarseilleMarseille 0-0 Lille | French Ligue 1 |
| 7 | Thu 9 Nov | 6 1-1 v Slovan BratislavaSlovan Bratislava 1-1 Lille | UEFA Europa Conference League |
| 8 | Sun 12 Nov | 6 1-1 v ToulouseLille 1-1 Toulouse | French Ligue 1 |
| 9 | Sun 26 Nov | 62-0 v LyonLyon 0-2 Lille | French Ligue 1 |
| 10 | Thu 30 Nov | 62-0 v Olimpija LjubljanaOlimpija Ljubljana 0-2 Lille | UEFA Europa Conference League |
| 11 | Sun 3 Dec | 62-0 v MetzLille 2-0 Metz | French Ligue 1 |
| 12 | Sun 10 Dec | 60-0 v ClermontClermont 0-0 Lille | French Ligue 1 |
| 13 | Thu 14 Dec | 6 3-0 v KÍ KlaksvíkLille 3-0 KÍ Klaksvík | UEFA Europa Conference League |
| 14 | Sun 17 Dec | 61-1 v Paris St GermainLille 1-1 Paris St Germain | French Ligue 1 |
| 15 | Wed 20 Dec | 61-2 v StrasbourgStrasbourg 2-1 Lille | French Ligue 1 |
| 16 | Sun 28 Jan | 60-0 v MontpellierMontpellier 0-0 Lille | French Ligue 1 |
| 17 | Sun 4 Feb | 64-0 v ClermontLille 4-0 Clermont | French Ligue 1 |
| 18 | Sat 10 Feb | 61-3 v Paris St GermainParis St Germain 3-1 Lille | French Ligue 1 |
| 19 | Sat 17 Feb | 6 3-0 v Le HavreLille 3-0 Le Havre | French Ligue 1 |
| 20 | Sun 25 Feb | 61-3 v ToulouseToulouse 3-1 Lille | French Ligue 1 |
| 21 | Sat 2 Mar | 61-0 v ReimsReims 0-1 Lille | French Ligue 1 |
| 22 | Sun 10 Mar | 6 2-2 v RennesLille 2-2 Rennes | French Ligue 1 |
| 23 | Thu 14 Mar | 61-1 v Sturm GrazLille 1-1 Sturm Graz | UEFA Europa Conference League Round of 16 |
| 24 | Sun 17 Mar | 61-1 v BrestBrest 1-1 Lille | French Ligue 1 |
| 25 | Fri 29 Mar | 6 2-1 v LensLille 2-1 Lens | French Ligue 1 |
| 26 | Fri 5 Apr | 63-1 v MarseilleLille 3-1 Marseille | French Ligue 1 |
| 27 | Thu 11 Apr | 61-2 v Aston VillaAston Villa 2-1 Lille | UEFA Europa Conference League Quarter Final |
| 28 | Thu 18 Apr | 6 2-1 v Aston VillaLille 2-1 Aston Villa | UEFA Europa Conference League Quarter Final |
| 29 | Wed 24 Apr | 60-1 v MonacoMonaco 1-0 Lille | French Ligue 1 |
| 30 | Sun 28 Apr | 6 2-1 v MetzMetz 1-2 Lille | French Ligue 1 |
| 31 | Mon 6 May | 63-4 v LyonLille 3-4 Lyon | French Ligue 1 |
| 32 | Sun 12 May | 6 2-1 v NantesNantes 1-2 Lille | French Ligue 1 |
| 33 | Sun 19 May | 62-2 v NiceLille 2-2 Nice | French Ligue 1 |
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