| 1 | Sat 18 Sep 2021 | 53-0 v Crystal PalaceLiverpool 3-0 Crystal Palace | Premier League |
| 2 | Tue 21 Sep 2021 | 53-0 v Norwich CityNorwich City 0-3 Liverpool | Carabao Cup Third Round |
| 3 | Sun 24 Oct 2021 | 55-0 v Manchester UnitedManchester United 0-5 Liverpool | Premier League |
| 4 | Sat 30 Oct 2021 | 52-2 v Brighton & Hove AlbionLiverpool 2-2 Brighton & Hove Albion | Premier League |
| 5 | Wed 24 Nov 2021 | 5 2-0 v FC PortoLiverpool 2-0 FC Porto | UEFA Champions League Group B |
| 6 | Sat 27 Nov 2021 | 54-0 v SouthamptonLiverpool 4-0 Southampton | Premier League |
| 7 | Tue 7 Dec 2021 | 52-1 v AC MilanAC Milan 1-2 Liverpool | UEFA Champions League Group B |
| 8 | Thu 16 Dec 2021 | 53-1 v Newcastle UnitedLiverpool 3-1 Newcastle United | Premier League |
| 9 | Sun 19 Dec 2021 | 5 2-2 v Tottenham HotspurTottenham Hotspur 2-2 Liverpool | Premier League |
| 10 | Wed 22 Dec 2021 | 53-3 v Leicester CityLiverpool 3-3 Leicester City | Carabao Cup Quarter Final |
| 11 | Sun 2 Jan 2022 | 5 2-2 v ChelseaChelsea 2-2 Liverpool | Premier League |
| 12 | Sun 9 Jan 2022 | 54-1 v Shrewsbury TownLiverpool 4-1 Shrewsbury Town | Emirates FA Cup Third Round |
| 13 | Thu 20 Jan 2022 | 5 2-0 v ArsenalArsenal 0-2 Liverpool | Carabao Cup Semi Final |
| 14 | Sun 6 Feb 2022 | 53-1 v Cardiff CityLiverpool 3-1 Cardiff City | Emirates FA Cup Fourth Round |
| 15 | Wed 16 Feb 2022 | 52-0 v Inter MilanInter Milan 0-2 Liverpool | UEFA Champions League Round of 16 |
| 16 | Sun 27 Feb 2022 | 50-0 v ChelseaChelsea 0-0 Liverpool | Carabao Cup Final |
| 17 | Wed 2 Mar 2022 | 52-1 v Norwich CityLiverpool 2-1 Norwich City | Emirates FA Cup Fifth Round |
| 18 | Sat 5 Mar 2022 | 51-0 v West Ham UnitedLiverpool 1-0 West Ham United | Premier League |
| 19 | Sun 20 Mar 2022 | 51-0 v Nottingham ForestNottingham Forest 0-1 Liverpool | Emirates FA Cup Sixth Round |
| 20 | Tue 5 Apr 2022 | 53-1 v BenficaBenfica 1-3 Liverpool | UEFA Champions League Quarter Final |
| 21 | Wed 13 Apr 2022 | 53-3 v BenficaLiverpool 3-3 Benfica | UEFA Champions League Quarter Final |
| 22 | Sat 16 Apr 2022 | 53-2 v Manchester CityManchester City 2-3 Liverpool | Emirates FA Cup Semi Final |
| 23 | Wed 27 Apr 2022 | 52-0 v VillarrealLiverpool 2-0 Villarreal | UEFA Champions League Semi Final |
| 24 | Tue 3 May 2022 | 53-2 v VillarrealVillarreal 2-3 Liverpool | UEFA Champions League Semi Final |
| 25 | Sat 7 May 2022 | 51-1 v Tottenham HotspurLiverpool 1-1 Tottenham Hotspur | Premier League |
| 26 | Sat 14 May 2022 | 50-0 v ChelseaChelsea 0-0 Liverpool | Emirates FA Cup Final |
| 27 | Tue 17 May 2022 | 52-1 v SouthamptonSouthampton 1-2 Liverpool | Premier League |
| 28 | Sun 22 May 2022 | 53-1 v Wolverhampton WanderersLiverpool 3-1 Wolverhampton Wanderers | Premier League |
| 29 | Sat 28 May 2022 | 50-1 v Real MadridLiverpool 0-1 Real Madrid | UEFA Champions League Final |
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