| 1 | Sat 11 Sep 2021 | 52-2 v Blackburn RoversBlackburn Rovers 2-2 Luton Town | Sky Bet Championship |
| 2 | Wed 15 Sep 2021 | 51-1 v Bristol CityBristol City 1-1 Luton Town | Sky Bet Championship |
| 3 | Wed 29 Sep 2021 | 55-0 v Coventry CityLuton Town 5-0 Coventry City | Sky Bet Championship |
| 4 | Sat 2 Oct 2021 | 50-0 v Huddersfield TownLuton Town 0-0 Huddersfield Town | Sky Bet Championship |
| 5 | Sat 16 Oct 2021 | 52-0 v MillwallMillwall 0-2 Luton Town | Sky Bet Championship |
| 6 | Sat 23 Oct 2021 | 51-0 v Hull CityLuton Town 1-0 Hull City | Sky Bet Championship |
| 7 | Sat 30 Oct 2021 | 50-2 v Preston North EndPreston North End 2-0 Luton Town | Sky Bet Championship |
| 8 | Tue 2 Nov 2021 | 53-1 v MiddlesbroughLuton Town 3-1 Middlesbrough | Sky Bet Championship |
| 9 | Sat 6 Nov 2021 | 50-1 v Stoke CityLuton Town 0-1 Stoke City | Sky Bet Championship |
| 10 | Fri 19 Nov 2021 | 5 0-2 v Queens Park RangersQueens Park Rangers 2-0 Luton Town | Sky Bet Championship |
| 11 | Tue 23 Nov 2021 | 5 0-0 v Nottingham ForestNottingham Forest 0-0 Luton Town | Sky Bet Championship |
| 12 | Sat 27 Nov 2021 | 51-2 v Cardiff CityLuton Town 1-2 Cardiff City | Sky Bet Championship |
| 13 | Sat 4 Dec 2021 | 53-0 v BlackpoolBlackpool 0-3 Luton Town | Sky Bet Championship |
| 14 | Sat 11 Dec 2021 | 51-1 v FulhamLuton Town 1-1 Fulham | Sky Bet Championship |
| 15 | Sun 9 Jan 2022 | 54-0 v Harrogate TownLuton Town 4-0 Harrogate Town | Emirates FA Cup Third Round |
| 16 | Sat 15 Jan 2022 | 53-2 v AFC BournemouthLuton Town 3-2 AFC Bournemouth | Sky Bet Championship |
| 17 | Wed 19 Jan 2022 | 52-0 v ReadingReading 0-2 Luton Town | Sky Bet Championship |
| 18 | Sat 22 Jan 2022 | 50-2 v Sheffield UnitedSheffield United 2-0 Luton Town | Sky Bet Championship |
| 19 | Tue 5 Apr 2022 | 51-1 v Peterborough UnitedPeterborough United 1-1 Luton Town | Sky Bet Championship |
| 20 | Mon 11 Apr 2022 | 50-2 v Huddersfield TownHuddersfield Town 2-0 Luton Town | Sky Bet Championship |
| 21 | Fri 15 Apr 2022 | 5 1-0 v Nottingham ForestLuton Town 1-0 Nottingham Forest | Sky Bet Championship |
| 22 | Sat 23 Apr 2022 | 51-1 v BlackpoolLuton Town 1-1 Blackpool | Sky Bet Championship |
| 23 | Sat 7 May 2022 | 51-0 v ReadingLuton Town 1-0 Reading | Sky Bet Championship |
| 24 | Fri 13 May 2022 | 51-1 v Huddersfield TownLuton Town 1-1 Huddersfield Town | Sky Bet Championship Play-off Semi Final |
| 25 | Mon 16 May 2022 | 50-1 v Huddersfield TownHuddersfield Town 1-0 Luton Town | Sky Bet Championship Play-off Semi Final |
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