| 1 | Sun 18 Aug | 80-3 v RennesRennes 3-0 Lyon | French Ligue 1 |
| 2 | Sat 24 Aug | 8 0-2 v MonacoLyon 0-2 Monaco | French Ligue 1 |
| 3 | Fri 30 Aug | 84-3 v StrasbourgLyon 4-3 Strasbourg | French Ligue 1 |
| 4 | Sun 15 Sep | 80-0 v LensLens 0-0 Lyon | French Ligue 1 |
| 5 | Sun 22 Sep | 82-3 v MarseilleLyon 2-3 Marseille | French Ligue 1 |
| 6 | Thu 26 Sep | 82-0 v OlympiakosLyon 2-0 Olympiakos | UEFA Europa League Matchday 1 |
| 7 | Sun 29 Sep | 82-1 v ToulouseToulouse 1-2 Lyon | French Ligue 1 |
| 8 | Thu 3 Oct | 84-1 v RangersRangers 1-4 Lyon | UEFA Europa League Matchday 2 |
| 9 | Sun 6 Oct | 82-0 v NantesLyon 2-0 Nantes | French Ligue 1 |
| 10 | Sun 20 Oct | 8 4-0 v Le HavreLe Havre 0-4 Lyon | French Ligue 1 |
| 11 | Thu 24 Oct | 8 0-1 v BeşiktaşLyon 0-1 Beşiktaş | UEFA Europa League Matchday 3 |
| 12 | Fri 1 Nov | 81-1 v LilleLille 1-1 Lyon | French Ligue 1 |
| 13 | Thu 7 Nov | 82-2 v 1899 Hoffenheim1899 Hoffenheim 2-2 Lyon | UEFA Europa League Matchday 4 |
| 14 | Sun 10 Nov | 81-0 v Saint ÉtienneLyon 1-0 Saint Étienne | French Ligue 1 |
| 15 | Sat 23 Nov | 81-1 v ReimsReims 1-1 Lyon | French Ligue 1 |
| 16 | Thu 28 Nov | 84-1 v FK QarabağFK Qarabağ 1-4 Lyon | UEFA Europa League Matchday 5 |
| 17 | Sun 1 Dec | 84-1 v NiceLyon 4-1 Nice | French Ligue 1 |
| 18 | Sat 7 Dec | 83-0 v AngersAngers 0-3 Lyon | French Ligue 1 |
| 19 | Thu 12 Dec | 83-2 v Eintracht FrankfurtLyon 3-2 Eintracht Frankfurt | UEFA Europa League Matchday 6 |
| 20 | Sun 15 Dec | 81-3 v Paris St GermainParis St Germain 3-1 Lyon | French Ligue 1 |
| 21 | Sat 4 Jan | 81-0 v MontpellierLyon 1-0 Montpellier | French Ligue 1 |
| 22 | Sat 11 Jan | 81-2 v BrestBrest 2-1 Lyon | French Ligue 1 |
| 23 | Sat 18 Jan | 80-0 v ToulouseLyon 0-0 Toulouse | French Ligue 1 |
| 24 | Thu 23 Jan | 8 0-0 v FenerbahçeFenerbahçe 0-0 Lyon | UEFA Europa League Matchday 7 |
| 25 | Sun 26 Jan | 81-1 v NantesNantes 1-1 Lyon | French Ligue 1 |
| 26 | Thu 30 Jan | 81-1 v LudogoretsLyon 1-1 Ludogorets | UEFA Europa League Matchday 8 |
| 27 | Sun 2 Feb | 82-3 v MarseilleMarseille 3-2 Lyon | French Ligue 1 |
| 28 | Sun 9 Feb | 84-0 v ReimsLyon 4-0 Reims | French Ligue 1 |
| 29 | Sun 16 Feb | 84-1 v MontpellierMontpellier 1-4 Lyon | French Ligue 1 |
| 30 | Sun 23 Feb | 82-3 v Paris St GermainLyon 2-3 Paris St Germain | French Ligue 1 |
| 31 | Sun 2 Mar | 82-1 v BrestLyon 2-1 Brest | French Ligue 1 |
| 32 | Thu 6 Mar | 83-1 v Steaua BucharestSteaua Bucharest 1-3 Lyon | UEFA Europa League Round of 16 |
| 33 | Sun 9 Mar | 8 2-0 v NiceNice 0-2 Lyon | French Ligue 1 |
| 34 | Thu 13 Mar | 84-0 v Steaua BucharestLyon 4-0 Steaua Bucharest | UEFA Europa League Round of 16 |
| 35 | Sun 16 Mar | 84-2 v Le HavreLyon 4-2 Le Havre | French Ligue 1 |
| 36 | Fri 28 Mar | 82-4 v StrasbourgStrasbourg 4-2 Lyon | French Ligue 1 |
| 37 | Sat 5 Apr | 8 2-1 v LilleLyon 2-1 Lille | French Ligue 1 |
| 38 | Thu 10 Apr | 82-2 v Manchester UnitedLyon 2-2 Manchester United | UEFA Europa League Quarter Final |
| 39 | Sun 13 Apr | 83-1 v AuxerreAuxerre 1-3 Lyon | French Ligue 1 |
| 40 | Thu 17 Apr | 8 4-5 v Manchester UnitedManchester United 5-4 Lyon | UEFA Europa League Quarter Final |
| 41 | Sun 20 Apr | 81-2 v Saint ÉtienneSaint Étienne 2-1 Lyon | French Ligue 1 |
| 42 | Sat 26 Apr | 84-1 v RennesLyon 4-1 Rennes | French Ligue 1 |
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