| 1 | Sun 18 Aug | 310-3 v RennesRennes 3-0 Lyon | French Ligue 1 |
| 2 | Sat 24 Aug | 310-2 v MonacoLyon 0-2 Monaco | French Ligue 1 |
| 3 | Fri 30 Aug | 314-3 v StrasbourgLyon 4-3 Strasbourg | French Ligue 1 |
| 4 | Sun 15 Sep | 310-0 v LensLens 0-0 Lyon | French Ligue 1 |
| 5 | Sun 22 Sep | 312-3 v MarseilleLyon 2-3 Marseille | French Ligue 1 |
| 6 | Thu 26 Sep | 312-0 v OlympiakosLyon 2-0 Olympiakos | UEFA Europa League Matchday 1 |
| 7 | Thu 3 Oct | 314-1 v RangersRangers 1-4 Lyon | UEFA Europa League Matchday 2 |
| 8 | Sun 27 Oct | 312-2 v AuxerreLyon 2-2 Auxerre | French Ligue 1 |
| 9 | Fri 1 Nov | 311-1 v LilleLille 1-1 Lyon | French Ligue 1 |
| 10 | Sun 10 Nov | 311-0 v Saint ÉtienneLyon 1-0 Saint Étienne | French Ligue 1 |
| 11 | Sat 23 Nov | 311-1 v ReimsReims 1-1 Lyon | French Ligue 1 |
| 12 | Thu 28 Nov | 314-1 v FK QarabağFK Qarabağ 1-4 Lyon | UEFA Europa League Matchday 5 |
| 13 | Sun 1 Dec | 314-1 v NiceLyon 4-1 Nice | French Ligue 1 |
| 14 | Sat 7 Dec | 313-0 v AngersAngers 0-3 Lyon | French Ligue 1 |
| 15 | Thu 12 Dec | 313-2 v Eintracht FrankfurtLyon 3-2 Eintracht Frankfurt | UEFA Europa League Matchday 6 |
| 16 | Sun 15 Dec | 311-3 v Paris St GermainParis St Germain 3-1 Lyon | French Ligue 1 |
| 17 | Sat 4 Jan | 311-0 v MontpellierLyon 1-0 Montpellier | French Ligue 1 |
| 18 | Sat 18 Jan | 310-0 v ToulouseLyon 0-0 Toulouse | French Ligue 1 |
| 19 | Thu 23 Jan | 310-0 v FenerbahçeFenerbahçe 0-0 Lyon | UEFA Europa League Matchday 7 |
| 20 | Sun 26 Jan | 311-1 v NantesNantes 1-1 Lyon | French Ligue 1 |
| 21 | Thu 30 Jan | 311-1 v LudogoretsLyon 1-1 Ludogorets | UEFA Europa League Matchday 8 |
| 22 | Sun 2 Feb | 312-3 v MarseilleMarseille 3-2 Lyon | French Ligue 1 |
| 23 | Sun 9 Feb | 314-0 v ReimsLyon 4-0 Reims | French Ligue 1 |
| 24 | Sun 16 Feb | 314-1 v MontpellierMontpellier 1-4 Lyon | French Ligue 1 |
| 25 | Sun 23 Feb | 312-3 v Paris St GermainLyon 2-3 Paris St Germain | French Ligue 1 |
| 26 | Sun 2 Mar | 312-1 v BrestLyon 2-1 Brest | French Ligue 1 |
| 27 | Thu 6 Mar | 313-1 v Steaua BucharestSteaua Bucharest 1-3 Lyon | UEFA Europa League Round of 16 |
| 28 | Sun 9 Mar | 312-0 v NiceNice 0-2 Lyon | French Ligue 1 |
| 29 | Thu 13 Mar | 314-0 v Steaua BucharestLyon 4-0 Steaua Bucharest | UEFA Europa League Round of 16 |
| 30 | Sun 16 Mar | 31 4-2 v Le HavreLyon 4-2 Le Havre | French Ligue 1 |
| 31 | Fri 28 Mar | 312-4 v StrasbourgStrasbourg 4-2 Lyon | French Ligue 1 |
| 32 | Sat 5 Apr | 312-1 v LilleLyon 2-1 Lille | French Ligue 1 |
| 33 | Sun 13 Apr | 313-1 v AuxerreAuxerre 1-3 Lyon | French Ligue 1 |
| 34 | Sat 26 Apr | 314-1 v RennesLyon 4-1 Rennes | French Ligue 1 |
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