| 1 | Sun 22 Sep | 32-3 v MarseilleLyon 2-3 Marseille | French Ligue 1 |
| 2 | Thu 26 Sep | 3 2-0 v OlympiakosLyon 2-0 Olympiakos | UEFA Europa League Matchday 1 |
| 3 | Thu 3 Oct | 34-1 v RangersRangers 1-4 Lyon | UEFA Europa League Matchday 2 |
| 4 | Sun 6 Oct | 3 2-0 v NantesLyon 2-0 Nantes | French Ligue 1 |
| 5 | Thu 24 Oct | 30-1 v BeşiktaşLyon 0-1 Beşiktaş | UEFA Europa League Matchday 3 |
| 6 | Sun 27 Oct | 32-2 v AuxerreLyon 2-2 Auxerre | French Ligue 1 |
| 7 | Fri 1 Nov | 31-1 v LilleLille 1-1 Lyon | French Ligue 1 |
| 8 | Sun 10 Nov | 31-0 v Saint ÉtienneLyon 1-0 Saint Étienne | French Ligue 1 |
| 9 | Thu 28 Nov | 3 4-1 v FK QarabağFK Qarabağ 1-4 Lyon | UEFA Europa League Matchday 5 |
| 10 | Sun 1 Dec | 3 4-1 v NiceLyon 4-1 Nice | French Ligue 1 |
| 11 | Sat 7 Dec | 33-0 v AngersAngers 0-3 Lyon | French Ligue 1 |
| 12 | Thu 12 Dec | 3 3-2 v Eintracht FrankfurtLyon 3-2 Eintracht Frankfurt | UEFA Europa League Matchday 6 |
| 13 | Sun 15 Dec | 3 1-3 v Paris St GermainParis St Germain 3-1 Lyon | French Ligue 1 |
| 14 | Sat 11 Jan | 31-2 v BrestBrest 2-1 Lyon | French Ligue 1 |
| 15 | Sat 18 Jan | 30-0 v ToulouseLyon 0-0 Toulouse | French Ligue 1 |
| 16 | Sun 26 Jan | 31-1 v NantesNantes 1-1 Lyon | French Ligue 1 |
| 17 | Sun 2 Feb | 3 2-3 v MarseilleMarseille 3-2 Lyon | French Ligue 1 |
| 18 | Sun 9 Feb | 3 4-0 v ReimsLyon 4-0 Reims | French Ligue 1 |
| 19 | Sun 16 Feb | 3 4-1 v MontpellierMontpellier 1-4 Lyon | French Ligue 1 |
| 20 | Sun 23 Feb | 32-3 v Paris St GermainLyon 2-3 Paris St Germain | French Ligue 1 |
| 21 | Thu 6 Mar | 33-1 v Steaua BucharestSteaua Bucharest 1-3 Lyon | UEFA Europa League Round of 16 |
| 22 | Sun 9 Mar | 32-0 v NiceNice 0-2 Lyon | French Ligue 1 |
| 23 | Sun 16 Mar | 34-2 v Le HavreLyon 4-2 Le Havre | French Ligue 1 |
| 24 | Sat 5 Apr | 32-1 v LilleLyon 2-1 Lille | French Ligue 1 |
| 25 | Thu 10 Apr | 3 2-2 v Manchester UnitedLyon 2-2 Manchester United | UEFA Europa League Quarter Final |
| 26 | Sun 13 Apr | 33-1 v AuxerreAuxerre 1-3 Lyon | French Ligue 1 |
| 27 | Thu 17 Apr | 3 4-5 v Manchester UnitedManchester United 5-4 Lyon | UEFA Europa League Quarter Final |
| 28 | Sat 26 Apr | 34-1 v RennesLyon 4-1 Rennes | French Ligue 1 |
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