| 1 | Sat 21 Aug 2021 | 280-2 v VfL BochumVfL Bochum 2-0 Mainz 05 | German Bundesliga |
| 2 | Sat 28 Aug 2021 | 283-0 v Greuther FürthMainz 05 3-0 Greuther Fürth | German Bundesliga |
| 3 | Sat 11 Sep 2021 | 282-0 v 1899 Hoffenheim1899 Hoffenheim 0-2 Mainz 05 | German Bundesliga |
| 4 | Sat 18 Sep 2021 | 280-0 v SC FreiburgMainz 05 0-0 SC Freiburg | German Bundesliga |
| 5 | Fri 22 Oct 2021 | 284-1 v FC AugsburgMainz 05 4-1 FC Augsburg | German Bundesliga |
| 6 | Sat 30 Oct 2021 | 282-1 v Arminia BielefeldArminia Bielefeld 1-2 Mainz 05 | German Bundesliga |
| 7 | Fri 5 Nov 2021 | 281-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 8 | Sun 21 Nov 2021 | 28 1-1 v 1. FC KölnMainz 05 1-1 1. FC Köln | German Bundesliga |
| 9 | Fri 26 Nov 2021 | 281-2 v VfB StuttgartVfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 10 | Sat 4 Dec 2021 | 283-0 v VfL WolfsburgMainz 05 3-0 VfL Wolfsburg | German Bundesliga |
| 11 | Sat 5 Feb 2022 | 282-0 v 1899 HoffenheimMainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 12 Feb 2022 | 281-1 v SC FreiburgSC Freiburg 1-1 Mainz 05 | German Bundesliga |
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