| 1 | Sun 20 Aug | 201-4 v 1 FC Union Berlin1 FC Union Berlin 4-1 Mainz 05 | German Bundesliga |
| 2 | Sun 27 Aug | 20 1-1 v Eintracht FrankfurtMainz 05 1-1 Eintracht Frankfurt | German Bundesliga |
| 3 | Sat 2 Sep | 200-4 v Werder BremenWerder Bremen 4-0 Mainz 05 | German Bundesliga |
| 4 | Sat 16 Sep | 201-3 v VfB StuttgartMainz 05 1-3 VfB Stuttgart | German Bundesliga |
| 5 | Sat 23 Sep | 201-2 v FC AugsburgFC Augsburg 2-1 Mainz 05 | German Bundesliga |
| 6 | Sat 30 Sep | 20 0-3 v Bayer 04 LeverkusenMainz 05 0-3 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Fri 6 Oct | 202-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-2 Mainz 05 | German Bundesliga |
| 8 | Sat 21 Oct | 201-3 v Bayern MunichMainz 05 1-3 Bayern Munich | German Bundesliga |
| 9 | Fri 27 Oct | 202-2 v VfL BochumVfL Bochum 2-2 Mainz 05 | German Bundesliga |
| 10 | Sat 4 Nov | 202-0 v RB LeipzigMainz 05 2-0 RB Leipzig | German Bundesliga |
| 11 | Sun 26 Nov | 20 1-1 v 1899 Hoffenheim1899 Hoffenheim 1-1 Mainz 05 | German Bundesliga |
| 12 | Sat 13 Jan | 20 1-1 v VfL WolfsburgMainz 05 1-1 VfL Wolfsburg | German Bundesliga |
| 13 | Sat 3 Feb | 200-1 v Werder BremenMainz 05 0-1 Werder Bremen | German Bundesliga |
| 14 | Wed 7 Feb | 201-1 v 1 FC Union BerlinMainz 05 1-1 1 FC Union Berlin | German Bundesliga |
| 15 | Sat 9 Mar | 201-8 v Bayern MunichBayern Munich 8-1 Mainz 05 | German Bundesliga |
| 16 | Sat 30 Mar | 200-0 v RB LeipzigRB Leipzig 0-0 Mainz 05 | German Bundesliga |
| 17 | Sat 6 Apr | 204-0 v Darmstadt 98Mainz 05 4-0 Darmstadt 98 | German Bundesliga |
| 18 | Sat 13 Apr | 204-1 v 1899 HoffenheimMainz 05 4-1 1899 Hoffenheim | German Bundesliga |
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