| 1 | 20/9/2020 | 351-3 v RB LeipzigRB Leipzig 3-1 Mainz 05 | German Bundesliga |
| 2 | 26/9/2020 | 351-4 v VfB StuttgartMainz 05 1-4 VfB Stuttgart | German Bundesliga |
| 3 | 2/10/2020 | 350-4 v 1. FC Union Berlin1. FC Union Berlin 4-0 Mainz 05 | German Bundesliga |
| 4 | 17/10/2020 | 350-1 v Bayer 04 LeverkusenMainz 05 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 5 | 24/10/2020 | 352-3 v Borussia MönchengladbachMainz 05 2-3 Borussia Mönchengladbach | German Bundesliga |
| 6 | 31/10/2020 | 351-3 v FC AugsburgFC Augsburg 3-1 Mainz 05 | German Bundesliga |
| 7 | 7/11/2020 | 352-2 v FC Schalke 04Mainz 05 2-2 FC Schalke 04 | German Bundesliga |
| 8 | 22/11/2020 | 353-1 v SC FreiburgSC Freiburg 1-3 Mainz 05 | German Bundesliga |
| 9 | 29/11/2020 | 351-1 v 1899 HoffenheimMainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 10 | 5/12/2020 | 351-2 v Arminia BielefeldArminia Bielefeld 2-1 Mainz 05 | German Bundesliga |
| 11 | 12/12/2020 | 350-1 v 1. FC KölnMainz 05 0-1 1. FC Köln | German Bundesliga |
| 12 | 15/12/2020 | 350-0 v Hertha BerlinHertha Berlin 0-0 Mainz 05 | German Bundesliga |
| 13 | 19/12/2020 | 35 0-1 v Werder BremenMainz 05 0-1 Werder Bremen | German Bundesliga |
| 14 | 3/1/2021 | 352-5 v Bayern MunichBayern Munich 5-2 Mainz 05 | German Bundesliga |
| 15 | 9/1/2021 | 350-2 v Eintracht FrankfurtMainz 05 0-2 Eintracht Frankfurt | German Bundesliga |
| 16 | 16/1/2021 | 351-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 17 | 19/1/2021 | 350-2 v VfL WolfsburgMainz 05 0-2 VfL Wolfsburg | German Bundesliga |
| 18 | 23/1/2021 | 353-2 v RB LeipzigMainz 05 3-2 RB Leipzig | German Bundesliga |
| 19 | 6/2/2021 | 35 1-0 v 1. FC Union BerlinMainz 05 1-0 1. FC Union Berlin | German Bundesliga |
| 20 | 13/2/2021 | 352-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 Mainz 05 | German Bundesliga |
| 21 | 20/2/2021 | 352-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Mainz 05 | German Bundesliga |
| 22 | 28/2/2021 | 350-1 v FC AugsburgMainz 05 0-1 FC Augsburg | German Bundesliga |
| 23 | 5/3/2021 | 350-0 v FC Schalke 04FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 24 | 13/3/2021 | 351-0 v SC FreiburgMainz 05 1-0 SC Freiburg | German Bundesliga |
| 25 | 21/3/2021 | 352-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 26 | 3/4/2021 | 35 1-1 v Arminia BielefeldMainz 05 1-1 Arminia Bielefeld | German Bundesliga |
| 27 | 11/4/2021 | 353-2 v 1. FC Köln1. FC Köln 2-3 Mainz 05 | German Bundesliga |
| 28 | 21/4/2021 | 351-0 v Werder BremenWerder Bremen 0-1 Mainz 05 | German Bundesliga |
| 29 | 24/4/2021 | 352-1 v Bayern MunichMainz 05 2-1 Bayern Munich | German Bundesliga |
| 30 | 3/5/2021 | 35 1-1 v Hertha BerlinMainz 05 1-1 Hertha Berlin | German Bundesliga |
| 31 | 9/5/2021 | 351-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Mainz 05 | German Bundesliga |
| 32 | 16/5/2021 | 351-3 v Borussia DortmundMainz 05 1-3 Borussia Dortmund | German Bundesliga |
| 33 | 22/5/2021 | 35 3-2 v VfL WolfsburgVfL Wolfsburg 2-3 Mainz 05 | German Bundesliga |
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