| 1 | Sun 15 Sep | 31-2 v Werder BremenMainz 05 1-2 Werder Bremen | German Bundesliga |
| 2 | Fri 20 Sep | 33-2 v FC AugsburgFC Augsburg 2-3 Mainz 05 | German Bundesliga |
| 3 | Sat 28 Sep | 3 0-2 v 1 FC HeidenheimMainz 05 0-2 1 FC Heidenheim | German Bundesliga |
| 4 | Sat 5 Oct | 3 3-0 v FC St PauliFC St Pauli 0-3 Mainz 05 | German Bundesliga |
| 5 | Sat 19 Oct | 30-2 v RB LeipzigMainz 05 0-2 RB Leipzig | German Bundesliga |
| 6 | Fri 25 Oct | 31-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 7 | Sat 14 Dec | 32-1 v Bayern MunichMainz 05 2-1 Bayern Munich | German Bundesliga |
| 8 | Sat 21 Dec | 33-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Mainz 05 | German Bundesliga |
| 9 | Sat 11 Jan | 32-0 v VfL BochumMainz 05 2-0 VfL Bochum | German Bundesliga |
| 10 | Sat 8 Feb | 3 0-0 v FC AugsburgMainz 05 0-0 FC Augsburg | German Bundesliga |
| 11 | Sun 16 Feb | 32-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 | German Bundesliga |
| 12 | Sat 22 Feb | 32-0 v FC St PauliMainz 05 2-0 FC St Pauli | German Bundesliga |
| 13 | Sat 1 Mar | 32-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 14 | Fri 7 Mar | 33-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 Mainz 05 | German Bundesliga |
| 15 | Sat 15 Mar | 32-2 v SC FreiburgMainz 05 2-2 SC Freiburg | German Bundesliga |
| 16 | Sun 30 Mar | 31-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 17 | Sat 5 Apr | 3 1-1 v Holstein KielMainz 05 1-1 Holstein Kiel | German Bundesliga |
| 18 | Sat 12 Apr | 30-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Mainz 05 | German Bundesliga |
| 19 | Sat 19 Apr | 32-2 v VfL WolfsburgMainz 05 2-2 VfL Wolfsburg | German Bundesliga |
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