| 1 | Sat 24 Aug | 181-1 v 1 FC Union BerlinMainz 05 1-1 1 FC Union Berlin | German Bundesliga |
| 2 | Sat 31 Aug | 183-3 v VfB StuttgartVfB Stuttgart 3-3 Mainz 05 | German Bundesliga |
| 3 | Sun 15 Sep | 181-2 v Werder BremenMainz 05 1-2 Werder Bremen | German Bundesliga |
| 4 | Fri 20 Sep | 18 3-2 v FC AugsburgFC Augsburg 2-3 Mainz 05 | German Bundesliga |
| 5 | Sat 5 Oct | 183-0 v FC St PauliFC St Pauli 0-3 Mainz 05 | German Bundesliga |
| 6 | Sat 19 Oct | 180-2 v RB LeipzigMainz 05 0-2 RB Leipzig | German Bundesliga |
| 7 | Fri 25 Oct | 18 1-1 v Borussia MönchengladbachMainz 05 1-1 Borussia Mönchengladbach | German Bundesliga |
| 8 | Sun 3 Nov | 180-0 v SC FreiburgSC Freiburg 0-0 Mainz 05 | German Bundesliga |
| 9 | Sat 9 Nov | 183-1 v Borussia DortmundMainz 05 3-1 Borussia Dortmund | German Bundesliga |
| 10 | Sun 24 Nov | 183-0 v Holstein KielHolstein Kiel 0-3 Mainz 05 | German Bundesliga |
| 11 | Sun 1 Dec | 182-0 v 1899 HoffenheimMainz 05 2-0 1899 Hoffenheim | German Bundesliga |
| 12 | Sun 8 Dec | 18 3-4 v VfL WolfsburgVfL Wolfsburg 4-3 Mainz 05 | German Bundesliga |
| 13 | Sat 14 Dec | 18 2-1 v Bayern MunichMainz 05 2-1 Bayern Munich | German Bundesliga |
| 14 | Sat 21 Dec | 18 3-1 v Eintracht FrankfurtEintracht Frankfurt 1-3 Mainz 05 | German Bundesliga |
| 15 | Sun 19 Jan | 181-2 v 1 FC Union Berlin1 FC Union Berlin 2-1 Mainz 05 | German Bundesliga |
| 16 | Sat 25 Jan | 182-0 v VfB StuttgartMainz 05 2-0 VfB Stuttgart | German Bundesliga |
| 17 | Fri 31 Jan | 180-1 v Werder BremenWerder Bremen 1-0 Mainz 05 | German Bundesliga |
| 18 | Sat 8 Feb | 180-0 v FC AugsburgMainz 05 0-0 FC Augsburg | German Bundesliga |
| 19 | Sun 16 Feb | 18 2-0 v 1 FC Heidenheim1 FC Heidenheim 0-2 Mainz 05 | German Bundesliga |
| 20 | Sat 22 Feb | 182-0 v FC St PauliMainz 05 2-0 FC St Pauli | German Bundesliga |
| 21 | Sat 1 Mar | 182-1 v RB LeipzigRB Leipzig 1-2 Mainz 05 | German Bundesliga |
| 22 | Fri 7 Mar | 183-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-3 Mainz 05 | German Bundesliga |
| 23 | Sat 15 Mar | 182-2 v SC FreiburgMainz 05 2-2 SC Freiburg | German Bundesliga |
| 24 | Sun 30 Mar | 181-3 v Borussia DortmundBorussia Dortmund 3-1 Mainz 05 | German Bundesliga |
| 25 | Sat 5 Apr | 18 1-1 v Holstein KielMainz 05 1-1 Holstein Kiel | German Bundesliga |
| 26 | Sat 19 Apr | 182-2 v VfL WolfsburgMainz 05 2-2 VfL Wolfsburg | German Bundesliga |
| 27 | Sat 26 Apr | 18 0-3 v Bayern MunichBayern Munich 3-0 Mainz 05 | German Bundesliga |
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