| 1 | Sat 16 Oct 2021 | 52-0 v BurnleyManchester City 2-0 Burnley | Premier League |
| 2 | Wed 27 Oct 2021 | 50-0 v West Ham UnitedWest Ham United 0-0 Manchester City | Carabao Cup Round of 16 |
| 3 | Sat 30 Oct 2021 | 50-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 4 | Wed 3 Nov 2021 | 54-1 v Club BruggeManchester City 4-1 Club Brugge | UEFA Champions League Group A |
| 5 | Sat 6 Nov 2021 | 52-0 v Manchester UnitedManchester United 0-2 Manchester City | Premier League |
| 6 | Sun 21 Nov 2021 | 53-0 v EvertonManchester City 3-0 Everton | Premier League |
| 7 | Wed 24 Nov 2021 | 52-1 v Paris St GermainManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 8 | Tue 7 Dec 2021 | 5 1-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
| 9 | Tue 14 Dec 2021 | 57-0 v Leeds UnitedManchester City 7-0 Leeds United | Premier League |
| 10 | Sun 19 Dec 2021 | 54-0 v Newcastle UnitedNewcastle United 0-4 Manchester City | Premier League |
| 11 | Sat 15 Jan 2022 | 51-0 v ChelseaManchester City 1-0 Chelsea | Premier League |
| 12 | Sat 5 Feb 2022 | 54-1 v FulhamManchester City 4-1 Fulham | Emirates FA Cup Fourth Round |
| 13 | Wed 9 Feb 2022 | 52-0 v BrentfordManchester City 2-0 Brentford | Premier League |
| 14 | Tue 15 Feb 2022 | 55-0 v Sporting LisbonSporting Lisbon 0-5 Manchester City | UEFA Champions League Round of 16 |
| 15 | Sat 26 Feb 2022 | 51-0 v EvertonEverton 0-1 Manchester City | Premier League |
| 16 | Tue 1 Mar 2022 | 52-0 v Peterborough UnitedPeterborough United 0-2 Manchester City | Emirates FA Cup Fifth Round |
| 17 | Sun 6 Mar 2022 | 54-1 v Manchester UnitedManchester City 4-1 Manchester United | Premier League |
| 18 | Wed 9 Mar 2022 | 50-0 v Sporting LisbonManchester City 0-0 Sporting Lisbon | UEFA Champions League Round of 16 |
| 19 | Mon 14 Mar 2022 | 50-0 v Crystal PalaceCrystal Palace 0-0 Manchester City | Premier League |
| 20 | Sun 20 Mar 2022 | 54-1 v SouthamptonSouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 21 | Tue 5 Apr 2022 | 51-0 v Atlético MadridManchester City 1-0 Atlético Madrid | UEFA Champions League Quarter Final |
| 22 | Sun 10 Apr 2022 | 52-2 v LiverpoolManchester City 2-2 Liverpool | Premier League |
| 23 | Wed 13 Apr 2022 | 50-0 v Atlético MadridAtlético Madrid 0-0 Manchester City | UEFA Champions League Quarter Final |
| 24 | Sat 16 Apr 2022 | 52-3 v LiverpoolManchester City 2-3 Liverpool | Emirates FA Cup Semi Final |
| 25 | Wed 20 Apr 2022 | 53-0 v Brighton & Hove AlbionManchester City 3-0 Brighton & Hove Albion | Premier League |
| 26 | Tue 26 Apr 2022 | 54-3 v Real MadridManchester City 4-3 Real Madrid | UEFA Champions League Semi Final |
| 27 | Sun 22 May 2022 | 53-2 v Aston VillaManchester City 3-2 Aston Villa | Premier League |
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