| 1 | 15/8/2021 | 50-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | 28/8/2021 | 55-0 v ArsenalManchester City 5-0 Arsenal | Premier League |
| 3 | 11/9/2021 | 51-0 v Leicester CityLeicester City 0-1 Manchester City | Premier League |
| 4 | 25/9/2021 | 51-0 v ChelseaChelsea 0-1 Manchester City | Premier League |
| 5 | 28/9/2021 | 50-2 v Paris St GermainParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 6 | 3/10/2021 | 52-2 v LiverpoolLiverpool 2-2 Manchester City | Premier League |
| 7 | 16/10/2021 | 52-0 v BurnleyManchester City 2-0 Burnley | Premier League |
| 8 | 23/10/2021 | 54-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-4 Manchester City | Premier League |
| 9 | 27/10/2021 | 50-0 v West Ham UnitedWest Ham United 0-0 Manchester City | Carabao Cup Round of 16 |
| 10 | 30/10/2021 | 50-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 11 | 3/11/2021 | 54-1 v Club BruggeManchester City 4-1 Club Brugge | UEFA Champions League Group A |
| 12 | 6/11/2021 | 52-0 v Manchester UnitedManchester United 0-2 Manchester City | Premier League |
| 13 | 21/11/2021 | 53-0 v EvertonManchester City 3-0 Everton | Premier League |
| 14 | 24/11/2021 | 52-1 v Paris St GermainManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 15 | 28/11/2021 | 52-1 v West Ham UnitedManchester City 2-1 West Ham United | Premier League |
| 16 | 4/12/2021 | 53-1 v WatfordWatford 1-3 Manchester City | Premier League |
| 17 | 7/12/2021 | 5 1-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
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