| 1 | Fri 11 Aug | 63-0 v BurnleyBurnley 0-3 Manchester City | Premier League |
| 2 | Wed 16 Aug | 61-1 v SevillaManchester City 1-1 Sevilla | UEFA Super Cup Final |
| 3 | Sun 27 Aug | 62-1 v Sheffield UnitedSheffield United 1-2 Manchester City | Premier League |
| 4 | Sat 2 Sep | 65-1 v FulhamManchester City 5-1 Fulham | Premier League |
| 5 | Sat 16 Sep | 63-1 v West Ham UnitedWest Ham United 1-3 Manchester City | Premier League |
| 6 | Tue 19 Sep | 63-1 v Red Star BelgradeManchester City 3-1 Red Star Belgrade | UEFA Champions League Group G |
| 7 | Sat 23 Sep | 62-0 v Nottingham ForestManchester City 2-0 Nottingham Forest | Premier League |
| 8 | Wed 27 Sep | 60-1 v Newcastle UnitedNewcastle United 1-0 Manchester City | Carabao Cup Third Round |
| 9 | Sat 30 Sep | 61-2 v Wolverhampton WanderersWolverhampton Wanderers 2-1 Manchester City | Premier League |
| 10 | Wed 4 Oct | 63-1 v RB LeipzigRB Leipzig 1-3 Manchester City | UEFA Champions League Group G |
| 11 | Sun 8 Oct | 60-1 v ArsenalArsenal 1-0 Manchester City | Premier League |
| 12 | Sat 21 Oct | 62-1 v Brighton & Hove AlbionManchester City 2-1 Brighton & Hove Albion | Premier League |
| 13 | Wed 25 Oct | 63-1 v Young BoysYoung Boys 1-3 Manchester City | UEFA Champions League Group G |
| 14 | Sat 4 Nov | 66-1 v AFC BournemouthManchester City 6-1 AFC Bournemouth | Premier League |
| 15 | Tue 7 Nov | 63-0 v Young BoysManchester City 3-0 Young Boys | UEFA Champions League Group G |
| 16 | Sat 25 Nov | 61-1 v LiverpoolManchester City 1-1 Liverpool | Premier League |
| 17 | Tue 28 Nov | 63-2 v RB LeipzigManchester City 3-2 RB Leipzig | UEFA Champions League Group G |
| 18 | Sun 3 Dec | 63-3 v Tottenham HotspurManchester City 3-3 Tottenham Hotspur | Premier League |
| 19 | Sun 10 Dec | 62-1 v Luton TownLuton Town 1-2 Manchester City | Premier League |
| 20 | Wed 13 Dec | 63-2 v Red Star BelgradeRed Star Belgrade 2-3 Manchester City | UEFA Champions League Group G |
| 21 | Sat 16 Dec | 62-2 v Crystal PalaceManchester City 2-2 Crystal Palace | Premier League |
| 22 | Wed 27 Dec | 63-1 v EvertonEverton 1-3 Manchester City | Premier League |
| 23 | Sat 30 Dec | 62-0 v Sheffield UnitedManchester City 2-0 Sheffield United | Premier League |
| 24 | Sat 13 Jan | 63-2 v Newcastle UnitedNewcastle United 2-3 Manchester City | Premier League |
| 25 | Fri 26 Jan | 61-0 v Tottenham HotspurTottenham Hotspur 0-1 Manchester City | Emirates FA Cup Fourth Round |
| 26 | Wed 31 Jan | 63-1 v BurnleyManchester City 3-1 Burnley | Premier League |
| 27 | Mon 5 Feb | 63-1 v BrentfordBrentford 1-3 Manchester City | Premier League |
| 28 | Sat 10 Feb | 62-0 v EvertonManchester City 2-0 Everton | Premier League |
| 29 | Tue 13 Feb | 63-1 v FC CopenhagenFC Copenhagen 1-3 Manchester City | UEFA Champions League Round of 16 |
| 30 | Sat 17 Feb | 61-1 v ChelseaManchester City 1-1 Chelsea | Premier League |
| 31 | Sat 24 Feb | 61-0 v AFC BournemouthAFC Bournemouth 0-1 Manchester City | Premier League |
| 32 | Tue 27 Feb | 66-2 v Luton TownLuton Town 2-6 Manchester City | Emirates FA Cup Fifth Round |
| 33 | Sun 3 Mar | 63-1 v Manchester UnitedManchester City 3-1 Manchester United | Premier League |
| 34 | Sun 10 Mar | 61-1 v LiverpoolLiverpool 1-1 Manchester City | Premier League |
| 35 | Sun 31 Mar | 60-0 v ArsenalManchester City 0-0 Arsenal | Premier League |
| 36 | Sat 20 Apr | 61-0 v ChelseaManchester City 1-0 Chelsea | Emirates FA Cup Semi Final |
| 37 | Thu 25 Apr | 64-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-4 Manchester City | Premier League |
| 38 | Sun 28 Apr | 62-0 v Nottingham ForestNottingham Forest 0-2 Manchester City | Premier League |
| 39 | Sat 4 May | 65-1 v Wolverhampton WanderersManchester City 5-1 Wolverhampton Wanderers | Premier League |
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