| 1 | Sat 19 Sep 2020 | 21-3 v Crystal PalaceManchester United 1-3 Crystal Palace | Premier League |
| 2 | Sat 26 Sep 2020 | 23-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-3 Manchester United | Premier League |
| 3 | Wed 30 Sep 2020 | 2 3-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-3 Manchester United | Carabao Cup Fourth Round |
| 4 | Sat 17 Oct 2020 | 24-1 v Newcastle UnitedNewcastle United 1-4 Manchester United | Premier League |
| 5 | Tue 20 Oct 2020 | 22-1 v Paris St GermainParis St Germain 1-2 Manchester United | UEFA Champions League Group H |
| 6 | Sat 24 Oct 2020 | 20-0 v ChelseaManchester United 0-0 Chelsea | Premier League |
| 7 | Wed 28 Oct 2020 | 25-0 v RB LeipzigManchester United 5-0 RB Leipzig | UEFA Champions League Group H |
| 8 | Sun 1 Nov 2020 | 20-1 v ArsenalManchester United 0-1 Arsenal | Premier League |
| 9 | Sat 7 Nov 2020 | 23-1 v EvertonEverton 1-3 Manchester United | Premier League |
| 10 | Sat 21 Nov 2020 | 21-0 v West Bromwich AlbionManchester United 1-0 West Bromwich Albion | Premier League |
| 11 | Tue 24 Nov 2020 | 24-1 v İstanbul BaşakşehirManchester United 4-1 İstanbul Başakşehir | UEFA Champions League Group H |
| 12 | Sun 29 Nov 2020 | 23-2 v SouthamptonSouthampton 2-3 Manchester United | Premier League |
| 13 | Wed 2 Dec 2020 | 21-3 v Paris St GermainManchester United 1-3 Paris St Germain | UEFA Champions League Group H |
| 14 | Sat 5 Dec 2020 | 23-1 v West Ham UnitedWest Ham United 1-3 Manchester United | Premier League |
| 15 | Tue 8 Dec 2020 | 2 2-3 v RB LeipzigRB Leipzig 3-2 Manchester United | UEFA Champions League Group H |
| 16 | Sat 12 Dec 2020 | 20-0 v Manchester CityManchester United 0-0 Manchester City | Premier League |
| 17 | Thu 17 Dec 2020 | 23-2 v Sheffield UnitedSheffield United 2-3 Manchester United | Premier League |
| 18 | Sun 20 Dec 2020 | 26-2 v Leeds UnitedManchester United 6-2 Leeds United | Premier League |
| 19 | Sat 26 Dec 2020 | 22-2 v Leicester CityLeicester City 2-2 Manchester United | Premier League |
| 20 | Wed 6 Jan 2021 | 20-2 v Manchester CityManchester United 0-2 Manchester City | Carabao Cup Semi Final |
| 21 | Sun 17 Jan 2021 | 20-0 v LiverpoolLiverpool 0-0 Manchester United | Premier League |
| 22 | Sun 24 Jan 2021 | 2 3-2 v LiverpoolManchester United 3-2 Liverpool | Emirates FA Cup Fourth Round |
| 23 | Sat 30 Jan 2021 | 20-0 v ArsenalArsenal 0-0 Manchester United | Premier League |
| 24 | Tue 2 Feb 2021 | 29-0 v SouthamptonManchester United 9-0 Southampton | Premier League |
| 25 | Sat 6 Feb 2021 | 23-3 v EvertonManchester United 3-3 Everton | Premier League |
| 26 | Tue 9 Feb 2021 | 21-0 v West Ham UnitedManchester United 1-0 West Ham United | Emirates FA Cup Fifth Round |
| 27 | Sun 14 Feb 2021 | 21-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Manchester United | Premier League |
| 28 | Sun 21 Feb 2021 | 23-1 v Newcastle UnitedManchester United 3-1 Newcastle United | Premier League |
| 29 | Thu 25 Feb 2021 | 2 0-0 v Real SociedadManchester United 0-0 Real Sociedad | Europa League Round of 32 |
| 30 | Sun 28 Feb 2021 | 20-0 v ChelseaChelsea 0-0 Manchester United | Premier League |
| 31 | Sun 7 Mar 2021 | 22-0 v Manchester CityManchester City 0-2 Manchester United | Premier League |
| 32 | Sun 14 Mar 2021 | 21-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 33 | Thu 18 Mar 2021 | 21-0 v AC MilanAC Milan 0-1 Manchester United | Europa League Round of 16 |
| 34 | Sun 21 Mar 2021 | 21-3 v Leicester CityLeicester City 3-1 Manchester United | Emirates FA Cup Sixth Round |
| 35 | Sun 4 Apr 2021 | 22-1 v Brighton & Hove AlbionManchester United 2-1 Brighton & Hove Albion | Premier League |
| 36 | Thu 8 Apr 2021 | 22-0 v GranadaGranada 0-2 Manchester United | Europa League Quarter Final |
| 37 | Sun 11 Apr 2021 | 23-1 v Tottenham HotspurTottenham Hotspur 1-3 Manchester United | Premier League |
| 38 | Thu 15 Apr 2021 | 22-0 v GranadaManchester United 2-0 Granada | Europa League Quarter Final |
| 39 | Sun 18 Apr 2021 | 23-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 40 | Sun 25 Apr 2021 | 20-0 v Leeds UnitedLeeds United 0-0 Manchester United | Premier League |
| 41 | Thu 29 Apr 2021 | 26-2 v RomaManchester United 6-2 Roma | Europa League Semi Final |
| 42 | Sun 9 May 2021 | 23-1 v Aston VillaAston Villa 1-3 Manchester United | Premier League |
| 43 | Thu 13 May 2021 | 22-4 v LiverpoolManchester United 2-4 Liverpool | Premier League |
| 44 | Tue 18 May 2021 | 21-1 v FulhamManchester United 1-1 Fulham | Premier League |
| 45 | Wed 26 May 2021 | 21-1 v VillarrealVillarreal 1-1 Manchester United | Europa League Final |
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