| 1 | Wed 22 Sep 2021 | 360-1 v West Ham UnitedManchester United 0-1 West Ham United | Carabao Cup Third Round |
| 2 | Sun 5 Dec 2021 | 361-0 v Crystal PalaceManchester United 1-0 Crystal Palace | Premier League |
| 3 | Wed 8 Dec 2021 | 361-1 v Young BoysManchester United 1-1 Young Boys | UEFA Champions League Group F |
| 4 | Mon 3 Jan 2022 | 360-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 5 | Mon 10 Jan 2022 | 361-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 6 | Sat 15 Jan 2022 | 362-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 7 | Wed 19 Jan 2022 | 363-1 v BrentfordBrentford 1-3 Manchester United | Premier League |
| 8 | Sat 22 Jan 2022 | 361-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 9 | Fri 4 Feb 2022 | 361-1 v MiddlesbroughManchester United 1-1 Middlesbrough | Emirates FA Cup Fourth Round |
| 10 | Tue 8 Feb 2022 | 361-1 v BurnleyBurnley 1-1 Manchester United | Premier League |
| 11 | Sat 12 Feb 2022 | 361-1 v SouthamptonManchester United 1-1 Southampton | Premier League |
| 12 | Tue 15 Feb 2022 | 362-0 v Brighton & Hove AlbionManchester United 2-0 Brighton & Hove Albion | Premier League |
| 13 | Sun 20 Feb 2022 | 364-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 14 | Wed 23 Feb 2022 | 361-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 15 | Sat 26 Feb 2022 | 360-0 v WatfordManchester United 0-0 Watford | Premier League |
| 16 | Sun 6 Mar 2022 | 361-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 17 | Sat 12 Mar 2022 | 363-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 18 | Tue 15 Mar 2022 | 360-1 v Atlético MadridManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 19 | Sat 2 Apr 2022 | 361-1 v Leicester CityManchester United 1-1 Leicester City | Premier League |
| 20 | Sat 9 Apr 2022 | 360-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 21 | Sat 16 Apr 2022 | 363-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 22 | Tue 19 Apr 2022 | 360-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
| 23 | Sat 23 Apr 2022 | 361-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
| 24 | Thu 28 Apr 2022 | 361-1 v ChelseaManchester United 1-1 Chelsea | Premier League |
| 25 | Mon 2 May 2022 | 363-0 v BrentfordManchester United 3-0 Brentford | Premier League |
| 26 | Sat 7 May 2022 | 360-4 v Brighton & Hove AlbionBrighton & Hove Albion 4-0 Manchester United | Premier League |
| 27 | Sun 22 May 2022 | 360-1 v Crystal PalaceCrystal Palace 1-0 Manchester United | Premier League |
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