| 1 | Sat 14 Aug 2021 | 315-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | Sun 22 Aug 2021 | 311-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | Sat 11 Sep 2021 | 314-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 4 | Tue 14 Sep 2021 | 311-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 5 | Sun 19 Sep 2021 | 312-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 6 | Wed 22 Sep 2021 | 310-1 v West Ham UnitedManchester United 0-1 West Ham United | Carabao Cup Third Round |
| 7 | Wed 29 Sep 2021 | 312-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 8 | Sat 16 Oct 2021 | 312-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 9 | Wed 20 Oct 2021 | 31 3-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 10 | Sat 30 Oct 2021 | 313-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 11 | Tue 2 Nov 2021 | 312-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 12 | Sat 20 Nov 2021 | 311-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 13 | Tue 23 Nov 2021 | 312-0 v VillarrealVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 14 | Sun 28 Nov 2021 | 311-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 15 | Wed 8 Dec 2021 | 311-1 v Young BoysManchester United 1-1 Young Boys | UEFA Champions League Group F |
| 16 | Mon 27 Dec 2021 | 311-1 v Newcastle UnitedNewcastle United 1-1 Manchester United | Premier League |
| 17 | Thu 30 Dec 2021 | 313-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 18 | Mon 3 Jan 2022 | 31 0-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 19 | Sat 15 Jan 2022 | 31 2-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 20 | Wed 19 Jan 2022 | 313-1 v BrentfordBrentford 1-3 Manchester United | Premier League |
| 21 | Wed 23 Feb 2022 | 311-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 22 | Sat 26 Feb 2022 | 310-0 v WatfordManchester United 0-0 Watford | Premier League |
| 23 | Sat 12 Mar 2022 | 313-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 24 | Tue 15 Mar 2022 | 31 0-1 v Atlético MadridManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 25 | Sat 2 Apr 2022 | 311-1 v Leicester CityManchester United 1-1 Leicester City | Premier League |
| 26 | Sat 9 Apr 2022 | 310-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 27 | Sat 16 Apr 2022 | 313-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 28 | Tue 19 Apr 2022 | 310-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
| 29 | Sat 23 Apr 2022 | 311-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
| 30 | Thu 28 Apr 2022 | 311-1 v ChelseaManchester United 1-1 Chelsea | Premier League |
| 31 | Mon 2 May 2022 | 31 3-0 v BrentfordManchester United 3-0 Brentford | Premier League |
| 32 | Sat 7 May 2022 | 310-4 v Brighton & Hove AlbionBrighton & Hove Albion 4-0 Manchester United | Premier League |
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