| 1 | Sat 14 Aug 2021 | 65-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | Sun 22 Aug 2021 | 6 1-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | Sun 29 Aug 2021 | 6 1-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | Sat 11 Sep 2021 | 6 4-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 5 | Tue 14 Sep 2021 | 61-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 6 | Sun 19 Sep 2021 | 62-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 7 | Sat 25 Sep 2021 | 60-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 8 | Wed 29 Sep 2021 | 62-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 9 | Sat 2 Oct 2021 | 61-1 v EvertonManchester United 1-1 Everton | Premier League |
| 10 | Sat 16 Oct 2021 | 6 2-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 11 | Wed 20 Oct 2021 | 63-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 12 | Sun 24 Oct 2021 | 6 0-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 13 | Tue 2 Nov 2021 | 62-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 14 | Fri 4 Feb 2022 | 6 1-1 v MiddlesbroughManchester United 1-1 Middlesbrough | Emirates FA Cup Fourth Round |
| 15 | Tue 8 Feb 2022 | 61-1 v BurnleyBurnley 1-1 Manchester United | Premier League |
| 16 | Sat 12 Feb 2022 | 6 1-1 v SouthamptonManchester United 1-1 Southampton | Premier League |
| 17 | Tue 15 Feb 2022 | 62-0 v Brighton & Hove AlbionManchester United 2-0 Brighton & Hove Albion | Premier League |
| 18 | Sun 20 Feb 2022 | 64-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 19 | Wed 23 Feb 2022 | 61-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 20 | Sat 26 Feb 2022 | 60-0 v WatfordManchester United 0-0 Watford | Premier League |
| 21 | Sun 6 Mar 2022 | 61-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 22 | Sat 12 Mar 2022 | 6 3-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 23 | Tue 15 Mar 2022 | 60-1 v Atlético MadridManchester United 0-1 Atlético Madrid | UEFA Champions League Round of 16 |
| 24 | Sat 2 Apr 2022 | 61-1 v Leicester CityManchester United 1-1 Leicester City | Premier League |
| 25 | Sat 9 Apr 2022 | 6 0-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 26 | Sat 16 Apr 2022 | 63-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 27 | Tue 19 Apr 2022 | 60-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
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