| 1 | Sat 10 Aug | 51-1 v Manchester CityManchester City 1-1 Manchester United | Community Shield Final |
| 2 | Fri 16 Aug | 5 1-0 v FulhamManchester United 1-0 Fulham | Premier League |
| 3 | Sat 24 Aug | 51-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-1 Manchester United | Premier League |
| 4 | Sun 1 Sep | 50-3 v LiverpoolManchester United 0-3 Liverpool | Premier League |
| 5 | Sat 14 Sep | 5 3-0 v SouthamptonSouthampton 0-3 Manchester United | Premier League |
| 6 | Tue 17 Sep | 57-0 v BarnsleyManchester United 7-0 Barnsley | Carabao Cup Third Round |
| 7 | Wed 25 Sep | 51-1 v FC TwenteManchester United 1-1 FC Twente | UEFA Europa League Matchday 1 |
| 8 | Thu 3 Oct | 53-3 v FC PortoFC Porto 3-3 Manchester United | UEFA Europa League Matchday 2 |
| 9 | Sun 6 Oct | 5 0-0 v Aston VillaAston Villa 0-0 Manchester United | Premier League |
| 10 | Sun 1 Dec | 54-0 v EvertonManchester United 4-0 Everton | Premier League |
| 11 | Wed 4 Dec | 5 0-2 v ArsenalArsenal 2-0 Manchester United | Premier League |
| 12 | Sat 7 Dec | 52-3 v Nottingham ForestManchester United 2-3 Nottingham Forest | Premier League |
| 13 | Sun 15 Dec | 52-1 v Manchester CityManchester City 1-2 Manchester United | Premier League |
| 14 | Sun 22 Dec | 50-3 v AFC BournemouthManchester United 0-3 AFC Bournemouth | Premier League |
| 15 | Thu 26 Dec | 50-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Manchester United | Premier League |
| 16 | Mon 30 Dec | 50-2 v Newcastle UnitedManchester United 0-2 Newcastle United | Premier League |
| 17 | Sun 5 Jan | 5 2-2 v LiverpoolLiverpool 2-2 Manchester United | Premier League |
| 18 | Sun 12 Jan | 5 1-1 v ArsenalArsenal 1-1 Manchester United | Emirates FA Cup Third Round |
| 19 | Thu 16 Jan | 53-1 v SouthamptonManchester United 3-1 Southampton | Premier League |
| 20 | Sun 19 Jan | 5 1-3 v Brighton & Hove AlbionManchester United 1-3 Brighton & Hove Albion | Premier League |
| 21 | Thu 23 Jan | 52-1 v RangersManchester United 2-1 Rangers | UEFA Europa League Matchday 7 |
| 22 | Sun 26 Jan | 51-0 v FulhamFulham 0-1 Manchester United | Premier League |
| 23 | Sun 2 Feb | 5 0-2 v Crystal PalaceManchester United 0-2 Crystal Palace | Premier League |
| 24 | Fri 7 Feb | 52-1 v Leicester CityManchester United 2-1 Leicester City | Emirates FA Cup Fourth Round |
| 25 | Sun 16 Feb | 50-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester United | Premier League |
| 26 | Sat 22 Feb | 52-2 v EvertonEverton 2-2 Manchester United | Premier League |
| 27 | Wed 26 Feb | 53-2 v Ipswich TownManchester United 3-2 Ipswich Town | Premier League |
| 28 | Sun 2 Mar | 51-1 v FulhamManchester United 1-1 Fulham | Emirates FA Cup Fifth Round |
| 29 | Tue 1 Apr | 50-1 v Nottingham ForestNottingham Forest 1-0 Manchester United | Premier League |
| 30 | Sun 6 Apr | 50-0 v Manchester CityManchester United 0-0 Manchester City | Premier League |
| 31 | Thu 10 Apr | 52-2 v LyonLyon 2-2 Manchester United | UEFA Europa League Quarter Final |
| 32 | Thu 17 Apr | 5 5-4 v LyonManchester United 5-4 Lyon | UEFA Europa League Quarter Final |
| 33 | Sun 27 Apr | 51-1 v AFC BournemouthAFC Bournemouth 1-1 Manchester United | Premier League |
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