| 1 | 19/9/2020 | 5 1-3 v Crystal PalaceManchester United 1-3 Crystal Palace | Premier League |
| 2 | 22/9/2020 | 53-0 v Luton TownLuton Town 0-3 Manchester United | Carabao Cup Third Round |
| 3 | 26/9/2020 | 53-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-3 Manchester United | Premier League |
| 4 | 4/10/2020 | 51-6 v Tottenham HotspurManchester United 1-6 Tottenham Hotspur | Premier League |
| 5 | 17/10/2020 | 54-1 v Newcastle UnitedNewcastle United 1-4 Manchester United | Premier League |
| 6 | 24/10/2020 | 50-0 v ChelseaManchester United 0-0 Chelsea | Premier League |
| 7 | 28/10/2020 | 55-0 v RB LeipzigManchester United 5-0 RB Leipzig | UEFA Champions League Group H |
| 8 | 1/11/2020 | 5 0-1 v ArsenalManchester United 0-1 Arsenal | Premier League |
| 9 | 4/11/2020 | 51-2 v İstanbul Başakşehirİstanbul Başakşehir 2-1 Manchester United | UEFA Champions League Group H |
| 10 | 7/11/2020 | 53-1 v EvertonEverton 1-3 Manchester United | Premier League |
| 11 | 21/11/2020 | 51-0 v West Bromwich AlbionManchester United 1-0 West Bromwich Albion | Premier League |
| 12 | 24/11/2020 | 5 4-1 v İstanbul BaşakşehirManchester United 4-1 İstanbul Başakşehir | UEFA Champions League Group H |
| 13 | 29/11/2020 | 53-2 v SouthamptonSouthampton 2-3 Manchester United | Premier League |
| 14 | 2/12/2020 | 51-3 v Paris St GermainManchester United 1-3 Paris St Germain | UEFA Champions League Group H |
| 15 | 5/12/2020 | 53-1 v West Ham UnitedWest Ham United 1-3 Manchester United | Premier League |
| 16 | 8/12/2020 | 5 2-3 v RB LeipzigRB Leipzig 3-2 Manchester United | UEFA Champions League Group H |
| 17 | 12/12/2020 | 5 0-0 v Manchester CityManchester United 0-0 Manchester City | Premier League |
| 18 | 17/12/2020 | 53-2 v Sheffield UnitedSheffield United 2-3 Manchester United | Premier League |
| 19 | 20/12/2020 | 56-2 v Leeds UnitedManchester United 6-2 Leeds United | Premier League |
| 20 | 23/12/2020 | 52-0 v EvertonEverton 0-2 Manchester United | Carabao Cup Quarter Final |
| 21 | 26/12/2020 | 52-2 v Leicester CityLeicester City 2-2 Manchester United | Premier League |
| 22 | 29/12/2020 | 51-0 v Wolverhampton WanderersManchester United 1-0 Wolverhampton Wanderers | Premier League |
| 23 | 1/1/2021 | 5 2-1 v Aston VillaManchester United 2-1 Aston Villa | Premier League |
| 24 | 6/1/2021 | 50-2 v Manchester CityManchester United 0-2 Manchester City | Carabao Cup Semi Final |
| 25 | 9/1/2021 | 51-0 v WatfordManchester United 1-0 Watford | Emirates FA Cup Third Round |
| 26 | 12/1/2021 | 51-0 v BurnleyBurnley 0-1 Manchester United | Premier League |
| 27 | 17/1/2021 | 50-0 v LiverpoolLiverpool 0-0 Manchester United | Premier League |
| 28 | 20/1/2021 | 52-1 v FulhamFulham 1-2 Manchester United | Premier League |
| 29 | 24/1/2021 | 53-2 v LiverpoolManchester United 3-2 Liverpool | Emirates FA Cup Fourth Round |
| 30 | 27/1/2021 | 51-2 v Sheffield UnitedManchester United 1-2 Sheffield United | Premier League |
| 31 | 30/1/2021 | 5 0-0 v ArsenalArsenal 0-0 Manchester United | Premier League |
| 32 | 2/2/2021 | 5 9-0 v SouthamptonManchester United 9-0 Southampton | Premier League |
| 33 | 6/2/2021 | 53-3 v EvertonManchester United 3-3 Everton | Premier League |
| 34 | 9/2/2021 | 51-0 v West Ham UnitedManchester United 1-0 West Ham United | Emirates FA Cup Fifth Round |
| 35 | 14/2/2021 | 51-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Manchester United | Premier League |
| 36 | 18/2/2021 | 54-0 v Real SociedadReal Sociedad 0-4 Manchester United | Europa League Round of 32 |
| 37 | 21/2/2021 | 53-1 v Newcastle UnitedManchester United 3-1 Newcastle United | Premier League |
| 38 | 25/2/2021 | 50-0 v Real SociedadManchester United 0-0 Real Sociedad | Europa League Round of 32 |
| 39 | 28/2/2021 | 5 0-0 v ChelseaChelsea 0-0 Manchester United | Premier League |
| 40 | 3/3/2021 | 50-0 v Crystal PalaceCrystal Palace 0-0 Manchester United | Premier League |
| 41 | 7/3/2021 | 5 2-0 v Manchester CityManchester City 0-2 Manchester United | Premier League |
| 42 | 11/3/2021 | 51-1 v AC MilanManchester United 1-1 AC Milan | Europa League Round of 16 |
| 43 | 14/3/2021 | 51-0 v West Ham UnitedManchester United 1-0 West Ham United | Premier League |
| 44 | 18/3/2021 | 51-0 v AC MilanAC Milan 0-1 Manchester United | Europa League Round of 16 |
| 45 | 21/3/2021 | 5 1-3 v Leicester CityLeicester City 3-1 Manchester United | Emirates FA Cup Sixth Round |
| 46 | 4/4/2021 | 52-1 v Brighton & Hove AlbionManchester United 2-1 Brighton & Hove Albion | Premier League |
| 47 | 8/4/2021 | 5 2-0 v GranadaGranada 0-2 Manchester United | Europa League Quarter Final |
| 48 | 11/4/2021 | 5 3-1 v Tottenham HotspurTottenham Hotspur 1-3 Manchester United | Premier League |
| 49 | 18/4/2021 | 53-1 v BurnleyManchester United 3-1 Burnley | Premier League |
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