| 1 | Fri 16 Aug | 41-0 v FulhamManchester United 1-0 Fulham | Premier League |
| 2 | Sat 24 Aug | 41-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-1 Manchester United | Premier League |
| 3 | Sun 1 Sep | 4 0-3 v LiverpoolManchester United 0-3 Liverpool | Premier League |
| 4 | Sat 14 Sep | 43-0 v SouthamptonSouthampton 0-3 Manchester United | Premier League |
| 5 | Tue 17 Sep | 47-0 v BarnsleyManchester United 7-0 Barnsley | Carabao Cup Third Round |
| 6 | Sat 21 Sep | 40-0 v Crystal PalaceCrystal Palace 0-0 Manchester United | Premier League |
| 7 | Sun 29 Sep | 40-3 v Tottenham HotspurManchester United 0-3 Tottenham Hotspur | Premier League |
| 8 | Thu 3 Oct | 43-3 v FC PortoFC Porto 3-3 Manchester United | UEFA Europa League Matchday 2 |
| 9 | Sun 6 Oct | 40-0 v Aston VillaAston Villa 0-0 Manchester United | Premier League |
| 10 | Sat 19 Oct | 42-1 v BrentfordManchester United 2-1 Brentford | Premier League |
| 11 | Thu 24 Oct | 41-1 v FenerbahçeFenerbahçe 1-1 Manchester United | UEFA Europa League Matchday 3 |
| 12 | Sun 27 Oct | 4 1-2 v West Ham UnitedWest Ham United 2-1 Manchester United | Premier League |
| 13 | Wed 30 Oct | 45-2 v Leicester CityManchester United 5-2 Leicester City | Carabao Cup Round of 16 |
| 14 | Sun 3 Nov | 41-1 v ChelseaManchester United 1-1 Chelsea | Premier League |
| 15 | Sun 10 Nov | 43-0 v Leicester CityManchester United 3-0 Leicester City | Premier League |
| 16 | Sun 24 Nov | 41-1 v Ipswich TownIpswich Town 1-1 Manchester United | Premier League |
| 17 | Thu 28 Nov | 43-2 v FK Bodø/GlimtManchester United 3-2 FK Bodø/Glimt | UEFA Europa League Matchday 5 |
| 18 | Sun 1 Dec | 44-0 v EvertonManchester United 4-0 Everton | Premier League |
| 19 | Wed 4 Dec | 40-2 v ArsenalArsenal 2-0 Manchester United | Premier League |
| 20 | Sat 7 Dec | 42-3 v Nottingham ForestManchester United 2-3 Nottingham Forest | Premier League |
| 21 | Thu 12 Dec | 4 2-1 v Viktoria PlzenViktoria Plzen 1-2 Manchester United | UEFA Europa League Matchday 6 |
| 22 | Sun 15 Dec | 42-1 v Manchester CityManchester City 1-2 Manchester United | Premier League |
| 23 | Mon 30 Dec | 40-2 v Newcastle UnitedManchester United 0-2 Newcastle United | Premier League |
| 24 | Sun 5 Jan | 4 2-2 v LiverpoolLiverpool 2-2 Manchester United | Premier League |
| 25 | Sun 12 Jan | 41-1 v ArsenalArsenal 1-1 Manchester United | Emirates FA Cup Third Round |
| 26 | Thu 16 Jan | 43-1 v SouthamptonManchester United 3-1 Southampton | Premier League |
| 27 | Sun 19 Jan | 41-3 v Brighton & Hove AlbionManchester United 1-3 Brighton & Hove Albion | Premier League |
| 28 | Thu 23 Jan | 42-1 v RangersManchester United 2-1 Rangers | UEFA Europa League Matchday 7 |
| 29 | Sun 26 Jan | 41-0 v FulhamFulham 0-1 Manchester United | Premier League |
| 30 | Thu 30 Jan | 42-0 v Steaua BucharestSteaua Bucharest 0-2 Manchester United | UEFA Europa League Matchday 8 |
| 31 | Sun 2 Feb | 40-2 v Crystal PalaceManchester United 0-2 Crystal Palace | Premier League |
| 32 | Sun 16 Feb | 40-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester United | Premier League |
| 33 | Sat 22 Feb | 42-2 v EvertonEverton 2-2 Manchester United | Premier League |
| 34 | Wed 26 Feb | 43-2 v Ipswich TownManchester United 3-2 Ipswich Town | Premier League |
| 35 | Sun 2 Mar | 41-1 v FulhamManchester United 1-1 Fulham | Emirates FA Cup Fifth Round |
| 36 | Thu 6 Mar | 41-1 v Real SociedadReal Sociedad 1-1 Manchester United | UEFA Europa League Round of 16 |
| 37 | Sun 9 Mar | 41-1 v ArsenalManchester United 1-1 Arsenal | Premier League |
| 38 | Thu 13 Mar | 4 4-1 v Real SociedadManchester United 4-1 Real Sociedad | UEFA Europa League Round of 16 |
| 39 | Sun 16 Mar | 43-0 v Leicester CityLeicester City 0-3 Manchester United | Premier League |
| 40 | Tue 1 Apr | 40-1 v Nottingham ForestNottingham Forest 1-0 Manchester United | Premier League |
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