| 1 | 7/8/2021 | 32-1 v Bristol RoversMansfield Town 2-1 Bristol Rovers | Sky Bet League Two |
| 2 | 14/8/2021 | 32-1 v Newport CountyMansfield Town 2-1 Newport County | Sky Bet League Two |
| 3 | 17/8/2021 | 31-1 v Colchester UnitedColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 4 | 21/8/2021 | 32-3 v Bradford CityMansfield Town 2-3 Bradford City | Sky Bet League Two |
| 5 | 28/8/2021 | 30-1 v Swindon TownSwindon Town 1-0 Mansfield Town | Sky Bet League Two |
| 6 | 4/9/2021 | 31-3 v Harrogate TownMansfield Town 1-3 Harrogate Town | Sky Bet League Two |
| 7 | 11/9/2021 | 31-3 v WalsallWalsall 3-1 Mansfield Town | Sky Bet League Two |
| 8 | 18/9/2021 | 3 1-1 v RochdaleMansfield Town 1-1 Rochdale | Sky Bet League Two |
| 9 | 25/9/2021 | 30-0 v Leyton OrientLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 10 | 2/10/2021 | 3 0-1 v BarrowMansfield Town 0-1 Barrow | Sky Bet League Two |
| 11 | 9/10/2021 | 30-0 v Oldham AthleticMansfield Town 0-0 Oldham Athletic | Sky Bet League Two |
| 12 | 16/10/2021 | 30-2 v Northampton TownNorthampton Town 2-0 Mansfield Town | Sky Bet League Two |
| 13 | 19/10/2021 | 31-1 v Port ValeMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 14 | 30/10/2021 | 3 2-0 v Tranmere RoversMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 15 | 6/11/2021 | 31-0 v SunderlandSunderland 0-1 Mansfield Town | Emirates FA Cup First Round |
| 16 | 13/11/2021 | 32-1 v StevenageStevenage 1-2 Mansfield Town | Sky Bet League Two |
| 17 | 20/11/2021 | 33-1 v Scunthorpe UnitedMansfield Town 3-1 Scunthorpe United | Sky Bet League Two |
| 18 | 23/11/2021 | 30-2 v Sutton UnitedSutton United 2-0 Mansfield Town | Sky Bet League Two |
| 19 | 27/11/2021 | 3 2-1 v Crawley TownCrawley Town 1-2 Mansfield Town | Sky Bet League Two |
| 20 | 4/12/2021 | 33-2 v Doncaster RoversDoncaster Rovers 2-3 Mansfield Town | Emirates FA Cup Second Round |
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