| 1 | Sat 16 Sep 2017 | 1-2 v Hartlepool UnitedLeyton Orient 1-2 Hartlepool United | National League |
| 2 | Sat 23 Sep 2017 | 2-2 v Aldershot TownAldershot Town 2-2 Leyton Orient | National League |
| 3 | Sat 30 Sep 2017 | 1-2 v AFC FyldeLeyton Orient 1-2 AFC Fylde | National League |
| 4 | Wed 4 Oct 2017 | 1-2 v Tranmere RoversTranmere Rovers 2-1 Leyton Orient | National League |
| 5 | Sat 7 Oct 2017 | 2-2 v BarrowBarrow 2-2 Leyton Orient | National League |
| 6 | Sat 21 Oct 2017 | 0-1 v Macclesfield TownLeyton Orient 0-1 Macclesfield Town | National League |
| 7 | Tue 24 Oct 2017 | 0-2 v GatesheadLeyton Orient 0-2 Gateshead | National League |
| 8 | Sat 28 Oct 2017 | 2-2 v WrexhamWrexham 2-2 Leyton Orient | National League |
| 9 | Sat 11 Nov 2017 | 1-2 v Ebbsfleet UnitedEbbsfleet United 2-1 Leyton Orient | National League |
| 10 | Sat 18 Nov 2017 | 1-1 v Dover AthleticLeyton Orient 1-1 Dover Athletic | National League |
| 11 | Tue 21 Nov 2017 | 2-2 v ChesterLeyton Orient 2-2 Chester | National League |
| 12 | Sat 25 Nov 2017 | 0-3 v Torquay UnitedTorquay United 3-0 Leyton Orient | National League |
| 13 | Sat 2 Dec 2017 | 0-1 v Solihull MoorsSolihull Moors 1-0 Leyton Orient | National League |
| 14 | Sat 9 Dec 2017 | 4-1 v Sutton UnitedLeyton Orient 4-1 Sutton United | National League |
| 15 | Tue 26 Dec 2017 | 2-0 v Dagenham & RedbridgeLeyton Orient 2-0 Dagenham & Redbridge | National League |
| 16 | Sat 30 Dec 2017 | 0-1 v BromleyLeyton Orient 0-1 Bromley | National League |
| 17 | Mon 1 Jan 2018 | 0-0 v Dagenham & RedbridgeDagenham & Redbridge 0-0 Leyton Orient | National League |
| 18 | Sat 6 Jan 2018 | 0-0 v Boreham WoodLeyton Orient 0-0 Boreham Wood | National League |
| 19 | Sat 27 Jan 2018 | 2-3 v Aldershot TownLeyton Orient 2-3 Aldershot Town | National League |
| 20 | Tue 30 Jan 2018 | 2-1 v FC Halifax TownFC Halifax Town 1-2 Leyton Orient | National League |
| 21 | Sat 10 Feb 2018 | 1-1 v Tranmere RoversLeyton Orient 1-1 Tranmere Rovers | National League |
| 22 | Tue 20 Feb 2018 | 1-0 v ChesterChester 0-1 Leyton Orient | National League |
| 23 | Sat 24 Feb 2018 | 3-3 v GatesheadLeyton Orient 3-3 Gateshead | Buildbase FA Trophy Quarter Final |
| 24 | Tue 17 Apr 2018 | 0-1 v Hartlepool UnitedHartlepool United 1-0 Leyton Orient | National League |
| 25 | Sat 21 Apr 2018 | 1-0 v WrexhamLeyton Orient 1-0 Wrexham | National League |
| 26 | Tue 24 Apr 2018 | 0-1 v Maidenhead UnitedLeyton Orient 0-1 Maidenhead United | National League |
| 27 | Sat 28 Apr 2018 | 3-1 v GatesheadGateshead 1-3 Leyton Orient | National League |
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