| 1 | Sat 29 Jul 2017 | 83-0 v Saint-EtienneSaint-Etienne 0-3 Southampton | Friendly |
| 2 | Sat 5 Aug 2017 | 82-0 v SevillaSouthampton 2-0 Sevilla | Friendly |
| 3 | Sat 12 Aug 2017 | 80-0 v Swansea CitySouthampton 0-0 Swansea City | Premier League |
| 4 | Sat 19 Aug 2017 | 8 3-2 v West Ham UnitedSouthampton 3-2 West Ham United | Premier League |
| 5 | Sat 26 Aug 2017 | 80-0 v Huddersfield TownHuddersfield Town 0-0 Southampton | Premier League |
| 6 | Sat 9 Sep 2017 | 80-2 v WatfordSouthampton 0-2 Watford | Premier League |
| 7 | Sat 16 Sep 2017 | 81-0 v Crystal PalaceCrystal Palace 0-1 Southampton | Premier League |
| 8 | Sat 23 Sep 2017 | 80-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 9 | Sat 30 Sep 2017 | 81-2 v Stoke CityStoke City 2-1 Southampton | Premier League |
| 10 | Sun 15 Oct 2017 | 82-2 v Newcastle UnitedSouthampton 2-2 Newcastle United | Premier League |
| 11 | Sat 21 Oct 2017 | 81-0 v West Bromwich AlbionSouthampton 1-0 West Bromwich Albion | Premier League |
| 12 | Sun 29 Oct 2017 | 81-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 13 | Sat 4 Nov 2017 | 80-1 v BurnleySouthampton 0-1 Burnley | Premier League |
| 14 | Sat 18 Nov 2017 | 80-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 15 | Sun 26 Nov 2017 | 84-1 v EvertonSouthampton 4-1 Everton | Premier League |
| 16 | Sun 3 Dec 2017 | 81-1 v AFC BournemouthAFC Bournemouth 1-1 Southampton | Premier League |
| 17 | Sun 10 Dec 2017 | 81-1 v ArsenalSouthampton 1-1 Arsenal | Premier League |
| 18 | Wed 13 Dec 2017 | 81-4 v Leicester CitySouthampton 1-4 Leicester City | Premier League |
| 19 | Sat 23 Dec 2017 | 81-1 v Huddersfield TownSouthampton 1-1 Huddersfield Town | Premier League |
| 20 | Tue 2 Jan 2018 | 81-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 21 | Sat 6 Jan 2018 | 81-0 v FulhamFulham 0-1 Southampton | Emirates FA Cup Third Round |
| 22 | Sat 13 Jan 2018 | 82-2 v WatfordWatford 2-2 Southampton | Premier League |
| 23 | Sun 21 Jan 2018 | 81-1 v Tottenham HotspurSouthampton 1-1 Tottenham Hotspur | Premier League |
| 24 | Sat 27 Jan 2018 | 81-0 v WatfordSouthampton 1-0 Watford | Emirates FA Cup Fourth Round |
| 25 | Wed 31 Jan 2018 | 81-1 v Brighton & Hove AlbionSouthampton 1-1 Brighton & Hove Albion | Premier League |
| 26 | Sun 11 Feb 2018 | 80-2 v LiverpoolSouthampton 0-2 Liverpool | Premier League |
| 27 | Thu 19 Apr 2018 | 80-0 v Leicester CityLeicester City 0-0 Southampton | Premier League |
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