| 1 | Sat 5 Sep 2020 | 7 3-2 v Queens Park RangersPlymouth Argyle 3-2 Queens Park Rangers | Carabao Cup First Round South |
| 2 | Tue 15 Sep 2020 | 72-3 v Leyton OrientLeyton Orient 3-2 Plymouth Argyle | Carabao Cup Second Round |
| 3 | Sat 19 Sep 2020 | 7 4-4 v AFC WimbledonAFC Wimbledon 4-4 Plymouth Argyle | Sky Bet League One |
| 4 | Sat 26 Sep 2020 | 71-1 v Shrewsbury TownPlymouth Argyle 1-1 Shrewsbury Town | Sky Bet League One |
| 5 | Sat 3 Oct 2020 | 70-1 v Hull CityHull City 1-0 Plymouth Argyle | Sky Bet League One |
| 6 | Sat 10 Oct 2020 | 72-0 v Burton AlbionPlymouth Argyle 2-0 Burton Albion | Sky Bet League One |
| 7 | Sat 17 Oct 2020 | 72-1 v Northampton TownPlymouth Argyle 2-1 Northampton Town | Sky Bet League One |
| 8 | Tue 20 Oct 2020 | 7 0-2 v Lincoln CityLincoln City 2-0 Plymouth Argyle | Sky Bet League One |
| 9 | Sat 24 Oct 2020 | 71-1 v Wigan AthleticWigan Athletic 1-1 Plymouth Argyle | Sky Bet League One |
| 10 | Tue 27 Oct 2020 | 72-1 v Doncaster RoversPlymouth Argyle 2-1 Doncaster Rovers | Sky Bet League One |
| 11 | Tue 3 Nov 2020 | 74-2 v Swindon TownPlymouth Argyle 4-2 Swindon Town | Sky Bet League One |
| 12 | Tue 10 Nov 2020 | 7 3-1 v Newport CountyPlymouth Argyle 3-1 Newport County | Papa John’s Trophy Group 8 |
| 13 | Mon 16 Nov 2020 | 72-2 v PortsmouthPlymouth Argyle 2-2 Portsmouth | Sky Bet League One |
| 14 | Sat 21 Nov 2020 | 7 1-5 v Fleetwood TownFleetwood Town 5-1 Plymouth Argyle | Sky Bet League One |
| 15 | Tue 24 Nov 2020 | 70-1 v Peterborough UnitedPeterborough United 1-0 Plymouth Argyle | Sky Bet League One |
| 16 | Tue 1 Dec 2020 | 70-4 v RochdalePlymouth Argyle 0-4 Rochdale | Sky Bet League One |
| 17 | Sat 5 Dec 2020 | 7 1-2 v Ipswich TownPlymouth Argyle 1-2 Ipswich Town | Sky Bet League One |
| 18 | Sat 12 Dec 2020 | 70-3 v Bristol RoversBristol Rovers 3-0 Plymouth Argyle | Sky Bet League One |
| 19 | Tue 15 Dec 2020 | 71-2 v Crewe AlexandraCrewe Alexandra 2-1 Plymouth Argyle | Sky Bet League One |
| 20 | Sat 19 Dec 2020 | 71-0 v Milton Keynes DonsPlymouth Argyle 1-0 Milton Keynes Dons | Sky Bet League One |
| 21 | Sat 26 Dec 2020 | 72-2 v Charlton AthleticCharlton Athletic 2-2 Plymouth Argyle | Sky Bet League One |
| 22 | Tue 29 Dec 2020 | 72-3 v Oxford UnitedPlymouth Argyle 2-3 Oxford United | Sky Bet League One |
| 23 | Sat 2 Jan 2021 | 7 1-0 v GillinghamPlymouth Argyle 1-0 Gillingham | Sky Bet League One |
| 24 | Sat 9 Jan 2021 | 73-2 v Huddersfield TownHuddersfield Town 2-3 Plymouth Argyle | Emirates FA Cup Third Round |
| 25 | Sat 16 Jan 2021 | 71-1 v Crewe AlexandraPlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 26 | Tue 19 Jan 2021 | 72-1 v SunderlandSunderland 1-2 Plymouth Argyle | Sky Bet League One |
| 27 | Sat 23 Jan 2021 | 71-2 v Sheffield UnitedSheffield United 2-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 28 | Tue 26 Jan 2021 | 72-0 v Swindon TownSwindon Town 0-2 Plymouth Argyle | Sky Bet League One |
| 29 | Sat 6 Feb 2021 | 450-0 v Leyton OrientLeyton Orient 0-0 Colchester United | Sky Bet League Two |
| 30 | Sun 14 Feb 2021 | 452-2 v Mansfield TownColchester United 2-2 Mansfield Town | Sky Bet League Two |
| 31 | Sat 20 Feb 2021 | 450-1 v Crawley TownCrawley Town 1-0 Colchester United | Sky Bet League Two |
| 32 | Tue 23 Feb 2021 | 451-2 v Exeter CityColchester United 1-2 Exeter City | Sky Bet League Two |
| 33 | Sat 27 Feb 2021 | 450-3 v Forest Green RoversForest Green Rovers 3-0 Colchester United | Sky Bet League Two |
| 34 | Tue 2 Mar 2021 | 452-1 v Carlisle UnitedColchester United 2-1 Carlisle United | Sky Bet League Two |
| 35 | Sat 6 Mar 2021 | 45 0-2 v Newport CountyColchester United 0-2 Newport County | Sky Bet League Two |
| 36 | Sat 13 Mar 2021 | 450-0 v Grimsby TownGrimsby Town 0-0 Colchester United | Sky Bet League Two |
| 37 | Tue 16 Mar 2021 | 450-0 v Salford CitySalford City 0-0 Colchester United | Sky Bet League Two |
| 38 | Sat 20 Mar 2021 | 45 0-1 v Port ValeColchester United 0-1 Port Vale | Sky Bet League Two |
| 39 | Tue 23 Mar 2021 | 452-2 v Tranmere RoversColchester United 2-2 Tranmere Rovers | Sky Bet League Two |
| 40 | Sat 27 Mar 2021 | 451-2 v Bradford CityColchester United 1-2 Bradford City | Sky Bet League Two |
| 41 | Fri 2 Apr 2021 | 450-0 v Bolton WanderersBolton Wanderers 0-0 Colchester United | Sky Bet League Two |
| 42 | Mon 5 Apr 2021 | 451-1 v BarrowColchester United 1-1 Barrow | Sky Bet League Two |
| 43 | Fri 9 Apr 2021 | 452-5 v Oldham AthleticOldham Athletic 5-2 Colchester United | Sky Bet League Two |
| 44 | Sat 17 Apr 2021 | 452-1 v WalsallColchester United 2-1 Walsall | Sky Bet League Two |
| 45 | Tue 20 Apr 2021 | 452-0 v Southend UnitedColchester United 2-0 Southend United | Sky Bet League Two |
| 46 | Sat 24 Apr 2021 | 450-1 v Cheltenham TownCheltenham Town 1-0 Colchester United | Sky Bet League Two |
| 47 | Sat 1 May 2021 | 451-0 v Salford CityColchester United 1-0 Salford City | Sky Bet League Two |
| 48 | Sat 8 May 2021 | 450-0 v Tranmere RoversTranmere Rovers 0-0 Colchester United | Sky Bet League Two |
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