| 1 | Sat 9 Jan 2021 | 171-0 v BarrowSouthend United 1-0 Barrow | Sky Bet League Two |
| 2 | Sat 16 Jan 2021 | 170-0 v Grimsby TownGrimsby Town 0-0 Southend United | Sky Bet League Two |
| 3 | Sat 23 Jan 2021 | 170-1 v Mansfield TownSouthend United 0-1 Mansfield Town | Sky Bet League Two |
| 4 | Tue 26 Jan 2021 | 171-3 v Bradford CitySouthend United 1-3 Bradford City | Sky Bet League Two |
| 5 | Sat 30 Jan 2021 | 171-5 v Port ValePort Vale 5-1 Southend United | Sky Bet League Two |
| 6 | Tue 9 Feb 2021 | 171-0 v Newport CountyNewport County 0-1 Southend United | Sky Bet League Two |
| 7 | Sat 13 Feb 2021 | 170-0 v Cambridge UnitedCambridge United 0-0 Southend United | Sky Bet League Two |
| 8 | Sat 20 Feb 2021 | 170-1 v Bolton WanderersSouthend United 0-1 Bolton Wanderers | Sky Bet League Two |
| 9 | Wed 24 Feb 2021 | 173-1 v Forest Green RoversForest Green Rovers 1-3 Southend United | Sky Bet League Two |
| 10 | Sat 27 Feb 2021 | 17 0-0 v Salford CitySouthend United 0-0 Salford City | Sky Bet League Two |
| 11 | Sat 6 Mar 2021 | 170-0 v Oldham AthleticOldham Athletic 0-0 Southend United | Sky Bet League Two |
| 12 | Tue 9 Mar 2021 | 17 0-2 v Tranmere RoversSouthend United 0-2 Tranmere Rovers | Sky Bet League Two |
| 13 | Sat 13 Mar 2021 | 17 0-0 v StevenageSouthend United 0-0 Stevenage | Sky Bet League Two |
| 14 | Sat 20 Mar 2021 | 171-1 v Scunthorpe UnitedScunthorpe United 1-1 Southend United | Sky Bet League Two |
| 15 | Tue 23 Mar 2021 | 170-0 v WalsallSouthend United 0-0 Walsall | Sky Bet League Two |
| 16 | Sat 3 Apr 2021 | 170-2 v Carlisle UnitedSouthend United 0-2 Carlisle United | Sky Bet League Two |
| 17 | Tue 6 Apr 2021 | 171-1 v MorecambeMorecambe 1-1 Southend United | Sky Bet League Two |
| 18 | Sat 10 Apr 2021 | 170-0 v Crawley TownSouthend United 0-0 Crawley Town | Sky Bet League Two |
| 19 | Sat 17 Apr 2021 | 170-0 v Exeter CityExeter City 0-0 Southend United | Sky Bet League Two |
| 20 | Tue 20 Apr 2021 | 170-2 v Colchester UnitedColchester United 2-0 Southend United | Sky Bet League Two |
| 21 | Sat 24 Apr 2021 | 172-1 v Leyton OrientSouthend United 2-1 Leyton Orient | Sky Bet League Two |
| 22 | Sat 1 May 2021 | 172-1 v BarrowBarrow 1-2 Southend United | Sky Bet League Two |
| 23 | Sat 8 May 2021 | 171-1 v Newport CountySouthend United 1-1 Newport County | Sky Bet League Two |
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