| 1 | Mon 4 Jan 2021 | 441-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 2 | Tue 19 Jan 2021 | 442-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 3 | Sat 23 Jan 2021 | 441-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 4 | Thu 11 Feb 2021 | 442-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 5 | Mon 1 Mar 2021 | 440-1 v EvertonEverton 1-0 Southampton | Premier League |
| 6 | Sat 6 Mar 2021 | 442-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 7 | Sun 14 Mar 2021 | 441-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 8 | Sat 20 Mar 2021 | 443-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 9 | Sun 4 Apr 2021 | 443-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 10 | Mon 12 Apr 2021 | 440-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 11 | Sun 18 Apr 2021 | 440-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 12 | Sat 8 May 2021 | 440-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 13 | Tue 11 May 2021 | 443-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
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