| 1 | Fri 4 Sep 2020 | 5 0-1 v NetherlandsNetherlands 1-0 Poland | UEFA Nations League League A Group 1 |
| 2 | Mon 7 Sep 2020 | 5 2-1 v BosniaBosnia 1-2 Poland | UEFA Nations League League A Group 1 |
| 3 | Sat 12 Sep 2020 | 350-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 4 | Wed 16 Sep 2020 | 350-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 5 | Sun 20 Sep 2020 | 352-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 6 | Sat 26 Sep 2020 | 351-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 7 | Sun 4 Oct 2020 | 352-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 8 | Wed 14 Oct 2020 | 5 3-0 v BosniaPoland 3-0 Bosnia | UEFA Nations League League A Group 1 |
| 9 | Sat 17 Oct 2020 | 353-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 10 | Sun 25 Oct 2020 | 352-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 11 | Sun 1 Nov 2020 | 354-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 12 | Fri 6 Nov 2020 | 352-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 13 | Sun 15 Nov 2020 | 50-2 v ItalyItaly 2-0 Poland | UEFA Nations League League A Group 5 |
| 14 | Wed 18 Nov 2020 | 5 1-2 v NetherlandsPoland 1-2 Netherlands | UEFA Nations League League A Group 6 |
| 15 | Mon 23 Nov 2020 | 351-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 16 | Sun 29 Nov 2020 | 352-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 17 | Mon 7 Dec 2020 | 352-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 18 | Sun 13 Dec 2020 | 353-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 19 | Wed 16 Dec 2020 | 35 1-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 20 | Sat 19 Dec 2020 | 350-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 21 | Sat 26 Dec 2020 | 350-0 v FulhamFulham 0-0 Southampton | Premier League |
| 22 | Tue 29 Dec 2020 | 350-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 23 | Mon 4 Jan 2021 | 351-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 24 | Sat 16 Jan 2021 | 350-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 25 | Tue 19 Jan 2021 | 352-0 v Shrewsbury TownSouthampton 2-0 Shrewsbury Town | Emirates FA Cup Third Round |
| 26 | Sat 23 Jan 2021 | 351-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 27 | Tue 26 Jan 2021 | 351-3 v ArsenalSouthampton 1-3 Arsenal | Premier League |
| 28 | Sat 30 Jan 2021 | 350-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 29 | Tue 2 Feb 2021 | 35 0-9 v Manchester UnitedManchester United 9-0 Southampton | Premier League |
| 30 | Sat 6 Feb 2021 | 35 2-3 v Newcastle UnitedNewcastle United 3-2 Southampton | Premier League |
| 31 | Thu 11 Feb 2021 | 352-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 32 | Sun 14 Feb 2021 | 35 1-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 33 | Sat 20 Feb 2021 | 351-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 34 | Tue 23 Feb 2021 | 350-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 35 | Mon 1 Mar 2021 | 350-1 v EvertonEverton 1-0 Southampton | Premier League |
| 36 | Sat 6 Mar 2021 | 352-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 37 | Wed 10 Mar 2021 | 352-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 38 | Sun 14 Mar 2021 | 351-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 39 | Sat 20 Mar 2021 | 35 3-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 40 | Sun 4 Apr 2021 | 353-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 41 | Mon 12 Apr 2021 | 350-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 42 | Sun 18 Apr 2021 | 35 0-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 43 | Wed 21 Apr 2021 | 351-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 44 | Fri 30 Apr 2021 | 351-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 45 | Sat 8 May 2021 | 350-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 46 | Tue 11 May 2021 | 35 3-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 47 | Sun 23 May 2021 | 35 0-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
| 48 | Mon 14 Jun 2021 | 51-2 v SlovakiaPoland 1-2 Slovakia | European Championship Group E |
| 49 | Sat 19 Jun 2021 | 51-1 v SpainSpain 1-1 Poland | European Championship Group E |
| 50 | Wed 23 Jun 2021 | 52-3 v SwedenSweden 3-2 Poland | European Championship Group E |
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