| 1 | Sat 24 Oct 2020 | 60-2 v Atlético MadridAtlético Madrid 2-0 Real Betis | Spanish La Liga |
| 2 | Sun 1 Nov 2020 | 63-1 v ElcheReal Betis 3-1 Elche | Spanish La Liga |
| 3 | Sat 7 Nov 2020 | 62-5 v BarcelonaBarcelona 5-2 Real Betis | Spanish La Liga |
| 4 | Mon 23 Nov 2020 | 60-4 v Athletic BilbaoAthletic Bilbao 4-0 Real Betis | Spanish La Liga |
| 5 | Sun 6 Dec 2020 | 6 2-0 v OsasunaOsasuna 0-2 Real Betis | Spanish La Liga |
| 6 | Sun 13 Dec 2020 | 61-1 v VillarrealReal Betis 1-1 Villarreal | Spanish La Liga |
| 7 | Sun 20 Dec 2020 | 60-2 v GranadaGranada 2-0 Real Betis | Spanish La Liga |
| 8 | Wed 23 Dec 2020 | 61-0 v CádizReal Betis 1-0 Cádiz | Spanish La Liga |
| 9 | Tue 29 Dec 2020 | 63-4 v LevanteLevante 4-3 Real Betis | Spanish La Liga |
| 10 | Sat 2 Jan 2021 | 6 1-1 v SevillaReal Betis 1-1 Sevilla | Spanish La Liga |
| 11 | Mon 11 Jan 2021 | 62-0 v HuescaHuesca 0-2 Real Betis | Spanish La Liga |
| 12 | Wed 20 Jan 2021 | 6 2-1 v Celta VigoReal Betis 2-1 Celta Vigo | Spanish La Liga |
| 13 | Sat 23 Jan 2021 | 62-2 v Real SociedadReal Sociedad 2-2 Real Betis | Spanish La Liga |
| 14 | Mon 1 Feb 2021 | 61-0 v OsasunaReal Betis 1-0 Osasuna | Spanish La Liga |
| 15 | Sun 7 Feb 2021 | 6 2-3 v BarcelonaReal Betis 2-3 Barcelona | Spanish La Liga |
| 16 | Sun 14 Feb 2021 | 62-1 v VillarrealVillarreal 1-2 Real Betis | Spanish La Liga |
| 17 | Sun 28 Feb 2021 | 61-0 v CádizCádiz 0-1 Real Betis | Spanish La Liga |
| 18 | Sun 14 Mar 2021 | 60-1 v SevillaSevilla 1-0 Real Betis | Spanish La Liga |
| 19 | Fri 19 Mar 2021 | 62-0 v LevanteReal Betis 2-0 Levante | Spanish La Liga |
| 20 | Sun 4 Apr 2021 | 6 1-1 v ElcheElche 1-1 Real Betis | Spanish La Liga |
| 21 | Sun 18 Apr 2021 | 6 2-2 v ValenciaReal Betis 2-2 Valencia | Spanish La Liga |
| 22 | Sat 24 Apr 2021 | 60-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
| 23 | Sun 2 May 2021 | 6 1-1 v Real ValladolidReal Valladolid 1-1 Real Betis | Spanish La Liga |
| 24 | Mon 10 May 2021 | 6 2-1 v GranadaReal Betis 2-1 Granada | Spanish La Liga |
| 25 | Thu 13 May 2021 | 61-1 v EibarEibar 1-1 Real Betis | Spanish La Liga |
| 26 | Sun 16 May 2021 | 61-0 v HuescaReal Betis 1-0 Huesca | Spanish La Liga |
| 27 | Sat 22 May 2021 | 6 3-2 v Celta VigoCelta Vigo 2-3 Real Betis | Spanish La Liga |
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