| 1 | Sat 3 Oct 2020 | 15 1-2 v EibarReal Valladolid 1-2 Eibar | Spanish La Liga |
| 2 | Sun 18 Oct 2020 | 152-2 v HuescaHuesca 2-2 Real Valladolid | Spanish La Liga |
| 3 | Sun 25 Oct 2020 | 150-2 v AlavésReal Valladolid 0-2 Alavés | Spanish La Liga |
| 4 | Sun 8 Nov 2020 | 152-1 v Athletic BilbaoReal Valladolid 2-1 Athletic Bilbao | Spanish La Liga |
| 5 | Sat 19 Dec 2020 | 151-1 v SevillaSevilla 1-1 Real Valladolid | Spanish La Liga |
| 6 | Tue 29 Dec 2020 | 15 0-0 v CádizCádiz 0-0 Real Valladolid | Spanish La Liga |
| 7 | Sat 2 Jan 2021 | 151-0 v GetafeGetafe 0-1 Real Valladolid | Spanish La Liga |
| 8 | Sun 28 Feb 2021 | 15 1-1 v Celta VigoCelta Vigo 1-1 Real Valladolid | Spanish La Liga |
| 9 | Sat 6 Mar 2021 | 152-1 v GetafeReal Valladolid 2-1 Getafe | Spanish La Liga |
| 10 | Sat 13 Mar 2021 | 150-0 v OsasunaOsasuna 0-0 Real Valladolid | Spanish La Liga |
| 11 | Sat 20 Mar 2021 | 151-1 v SevillaReal Valladolid 1-1 Sevilla | Spanish La Liga |
| 12 | Sat 24 Apr 2021 | 151-1 v CádizReal Valladolid 1-1 Cádiz | Spanish La Liga |
| 13 | Wed 28 Apr 2021 | 15 2-2 v Athletic BilbaoAthletic Bilbao 2-2 Real Valladolid | Spanish La Liga |
| 14 | Sun 2 May 2021 | 151-1 v Real BetisReal Valladolid 1-1 Real Betis | Spanish La Liga |
| 15 | Sun 9 May 2021 | 150-3 v ValenciaValencia 3-0 Real Valladolid | Spanish La Liga |
| 16 | Thu 13 May 2021 | 15 0-2 v VillarrealReal Valladolid 0-2 Villarreal | Spanish La Liga |
| 17 | Sat 22 May 2021 | 15 1-2 v Atlético MadridReal Valladolid 1-2 Atlético Madrid | Spanish La Liga |
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