| 1 | Sun 15 Aug 2021 | 4 0-2 v KAA GentKAA Gent 2-0 Mechelen | Belgian First Division A |
| 2 | Fri 27 Aug 2021 | 42-2 v KV KortrijkKV Kortrijk 2-2 Mechelen | Belgian First Division A |
| 3 | Sun 12 Sep 2021 | 42-7 v RSC AnderlechtRSC Anderlecht 7-2 Mechelen | Belgian First Division A |
| 4 | Sat 18 Sep 2021 | 4 2-0 v Oud-Heverlee LeuvenMechelen 2-0 Oud-Heverlee Leuven | Belgian First Division A |
| 5 | Sun 26 Sep 2021 | 42-0 v Sporting de CharleroiSporting de Charleroi 0-2 Mechelen | Belgian First Division A |
| 6 | Fri 1 Oct 2021 | 43-1 v Standard LiègeMechelen 3-1 Standard Liège | Belgian First Division A |
| 7 | Sun 17 Oct 2021 | 41-0 v Germinal BeerschotGerminal Beerschot 0-1 Mechelen | Belgian First Division A |
| 8 | Sat 23 Oct 2021 | 42-2 v SV Zulte WaregemMechelen 2-2 SV Zulte Waregem | Belgian First Division A |
| 9 | Fri 29 Oct 2021 | 4 4-2 v KV OostendeKV Oostende 2-4 Mechelen | Belgian First Division A |
| 10 | Sat 6 Nov 2021 | 40-1 v Sint-Truidense VVMechelen 0-1 Sint-Truidense VV | Belgian First Division A |
| 11 | Fri 19 Nov 2021 | 42-1 v Club BruggeMechelen 2-1 Club Brugge | Belgian First Division A |
| 12 | Sat 27 Nov 2021 | 41-3 v Cercle BruggeCercle Brugge 3-1 Mechelen | Belgian First Division A |
| 13 | Sun 5 Dec 2021 | 41-1 v KRC GenkMechelen 1-1 KRC Genk | Belgian First Division A |
| 14 | Sat 18 Dec 2021 | 42-3 v SV Zulte WaregemSV Zulte Waregem 3-2 Mechelen | Belgian First Division A |
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