| 1 | Sat 14 Aug 2021 | 75-0 v NEC NijmegenAjax 5-0 NEC Nijmegen | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 71-1 v FC TwenteFC Twente 1-1 Ajax | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 75-0 v VitesseAjax 5-0 Vitesse | Dutch Eredivisie |
| 4 | Sat 11 Sep 2021 | 72-0 v PEC ZwollePEC Zwolle 0-2 Ajax | Dutch Eredivisie |
| 5 | Wed 15 Sep 2021 | 75-1 v Sporting LisbonSporting Lisbon 1-5 Ajax | UEFA Champions League Group C |
| 6 | Sat 25 Sep 2021 | 73-0 v FC GroningenAjax 3-0 FC Groningen | Dutch Eredivisie |
| 7 | Tue 28 Sep 2021 | 72-0 v BeşiktaşAjax 2-0 Beşiktaş | UEFA Champions League Group C |
| 8 | Sun 3 Oct 2021 | 70-1 v FC UtrechtAjax 0-1 FC Utrecht | Dutch Eredivisie |
| 9 | Sat 16 Oct 2021 | 72-0 v sc Heerenveensc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 10 | Tue 19 Oct 2021 | 74-0 v Borussia DortmundAjax 4-0 Borussia Dortmund | UEFA Champions League Group C |
| 11 | Sun 24 Oct 2021 | 75-0 v PSV EindhovenAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 12 | Sat 30 Oct 2021 | 70-0 v Heracles AlmeloHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 13 | Sun 7 Nov 2021 | 70-0 v Go Ahead EaglesAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 14 | Sun 21 Nov 2021 | 75-0 v RKC WaalwijkRKC Waalwijk 0-5 Ajax | Dutch Eredivisie |
| 15 | Wed 24 Nov 2021 | 72-1 v BeşiktaşBeşiktaş 1-2 Ajax | UEFA Champions League Group C |
| 16 | Sun 28 Nov 2021 | 7 1-0 v Sparta RotterdamSparta Rotterdam 0-1 Ajax | Dutch Eredivisie |
| 17 | Thu 2 Dec 2021 | 75-0 v Willem IIAjax 5-0 Willem II | Dutch Eredivisie |
| 18 | Tue 7 Dec 2021 | 74-2 v Sporting LisbonAjax 4-2 Sporting Lisbon | UEFA Champions League Group C |
| 19 | Wed 22 Dec 2021 | 75-0 v Fortuna SittardAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
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