| 1 | Sat 7 Aug 2021 | 2 3-0 v Peterborough UnitedLuton Town 3-0 Peterborough United | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 22-3 v West Bromwich AlbionWest Bromwich Albion 3-2 Luton Town | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 21-0 v BarnsleyBarnsley 0-1 Luton Town | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 20-5 v Birmingham CityLuton Town 0-5 Birmingham City | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 20-0 v Sheffield UnitedLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 22-2 v Blackburn RoversBlackburn Rovers 2-2 Luton Town | Sky Bet Championship |
| 7 | Wed 15 Sep 2021 | 2 1-1 v Bristol CityBristol City 1-1 Luton Town | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 23-3 v Swansea CityLuton Town 3-3 Swansea City | Sky Bet Championship |
| 9 | Sat 25 Sep 2021 | 21-2 v AFC BournemouthAFC Bournemouth 2-1 Luton Town | Sky Bet Championship |
| 10 | Wed 29 Sep 2021 | 25-0 v Coventry CityLuton Town 5-0 Coventry City | Sky Bet Championship |
| 11 | Sat 2 Oct 2021 | 20-0 v Huddersfield TownLuton Town 0-0 Huddersfield Town | Sky Bet Championship |
| 12 | Sat 16 Oct 2021 | 2 2-0 v MillwallMillwall 0-2 Luton Town | Sky Bet Championship |
| 13 | Sat 23 Oct 2021 | 21-0 v Hull CityLuton Town 1-0 Hull City | Sky Bet Championship |
| 14 | Sat 30 Oct 2021 | 20-2 v Preston North EndPreston North End 2-0 Luton Town | Sky Bet Championship |
| 15 | Tue 2 Nov 2021 | 2 3-1 v MiddlesbroughLuton Town 3-1 Middlesbrough | Sky Bet Championship |
| 16 | Sat 6 Nov 2021 | 20-1 v Stoke CityLuton Town 0-1 Stoke City | Sky Bet Championship |
| 17 | Fri 19 Nov 2021 | 20-2 v Queens Park RangersQueens Park Rangers 2-0 Luton Town | Sky Bet Championship |
| 18 | Tue 23 Nov 2021 | 20-0 v Nottingham ForestNottingham Forest 0-0 Luton Town | Sky Bet Championship |
| 19 | Sat 27 Nov 2021 | 21-2 v Cardiff CityLuton Town 1-2 Cardiff City | Sky Bet Championship |
| 20 | Sat 4 Dec 2021 | 23-0 v BlackpoolBlackpool 0-3 Luton Town | Sky Bet Championship |
| 21 | Sat 11 Dec 2021 | 21-1 v FulhamLuton Town 1-1 Fulham | Sky Bet Championship |
| 22 | Sun 9 Jan 2022 | 24-0 v Harrogate TownLuton Town 4-0 Harrogate Town | Emirates FA Cup Third Round |
| 23 | Sat 15 Jan 2022 | 23-2 v AFC BournemouthLuton Town 3-2 AFC Bournemouth | Sky Bet Championship |
| 24 | Tue 25 Jan 2022 | 22-1 v Bristol CityLuton Town 2-1 Bristol City | Sky Bet Championship |
| 25 | Sat 29 Jan 2022 | 2 0-0 v Blackburn RoversLuton Town 0-0 Blackburn Rovers | Sky Bet Championship |
| 26 | Tue 1 Feb 2022 | 21-0 v Swansea CitySwansea City 0-1 Luton Town | Sky Bet Championship |
| 27 | Tue 8 Feb 2022 | 22-1 v BarnsleyLuton Town 2-1 Barnsley | Sky Bet Championship |
| 28 | Sat 12 Feb 2022 | 20-3 v Birmingham CityBirmingham City 3-0 Luton Town | Sky Bet Championship |
| 29 | Sat 19 Feb 2022 | 22-0 v West Bromwich AlbionLuton Town 2-0 West Bromwich Albion | Sky Bet Championship |
| 30 | Wed 23 Feb 2022 | 22-1 v Stoke CityStoke City 1-2 Luton Town | Sky Bet Championship |
| 31 | Sat 26 Feb 2022 | 21-0 v Derby CountyLuton Town 1-0 Derby County | Sky Bet Championship |
| 32 | Sat 5 Mar 2022 | 21-2 v MiddlesbroughMiddlesbrough 2-1 Luton Town | Sky Bet Championship |
| 33 | Tue 8 Mar 2022 | 21-0 v Coventry CityCoventry City 0-1 Luton Town | Sky Bet Championship |
| 34 | Sun 13 Mar 2022 | 21-2 v Queens Park RangersLuton Town 1-2 Queens Park Rangers | Sky Bet Championship |
| 35 | Wed 16 Mar 2022 | 24-0 v Preston North EndLuton Town 4-0 Preston North End | Sky Bet Championship |
| 36 | Sat 19 Mar 2022 | 23-1 v Hull CityHull City 1-3 Luton Town | Sky Bet Championship |
| 37 | Sat 2 Apr 2022 | 22-2 v MillwallLuton Town 2-2 Millwall | Sky Bet Championship |
| 38 | Tue 5 Apr 2022 | 21-1 v Peterborough UnitedPeterborough United 1-1 Luton Town | Sky Bet Championship |
| 39 | Mon 11 Apr 2022 | 20-2 v Huddersfield TownHuddersfield Town 2-0 Luton Town | Sky Bet Championship |
| 40 | Fri 15 Apr 2022 | 21-0 v Nottingham ForestLuton Town 1-0 Nottingham Forest | Sky Bet Championship |
| 41 | Mon 18 Apr 2022 | 21-0 v Cardiff CityCardiff City 0-1 Luton Town | Sky Bet Championship |
| 42 | Sat 7 May 2022 | 21-0 v ReadingLuton Town 1-0 Reading | Sky Bet Championship |
| 43 | Fri 13 May 2022 | 21-1 v Huddersfield TownLuton Town 1-1 Huddersfield Town | Sky Bet Championship Play-off Semi Final |
| 44 | Mon 16 May 2022 | 20-1 v Huddersfield TownHuddersfield Town 1-0 Luton Town | Sky Bet Championship Play-off Semi Final |
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