| 1 | Sat 11 Sep 2021 | 322-0 v PEC ZwollePEC Zwolle 0-2 Ajax | Dutch Eredivisie |
| 2 | Wed 15 Sep 2021 | 325-1 v Sporting LisbonSporting Lisbon 1-5 Ajax | UEFA Champions League Group C |
| 3 | Tue 21 Sep 2021 | 325-0 v Fortuna SittardFortuna Sittard 0-5 Ajax | Dutch Eredivisie |
| 4 | Sat 25 Sep 2021 | 323-0 v FC GroningenAjax 3-0 FC Groningen | Dutch Eredivisie |
| 5 | Tue 28 Sep 2021 | 322-0 v BeşiktaşAjax 2-0 Beşiktaş | UEFA Champions League Group C |
| 6 | Sun 3 Oct 2021 | 320-1 v FC UtrechtAjax 0-1 FC Utrecht | Dutch Eredivisie |
| 7 | Sat 16 Oct 2021 | 322-0 v sc Heerenveensc Heerenveen 0-2 Ajax | Dutch Eredivisie |
| 8 | Tue 19 Oct 2021 | 324-0 v Borussia DortmundAjax 4-0 Borussia Dortmund | UEFA Champions League Group C |
| 9 | Sun 24 Oct 2021 | 325-0 v PSV EindhovenAjax 5-0 PSV Eindhoven | Dutch Eredivisie |
| 10 | Sat 30 Oct 2021 | 320-0 v Heracles AlmeloHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 11 | Wed 3 Nov 2021 | 323-1 v Borussia DortmundBorussia Dortmund 1-3 Ajax | UEFA Champions League Group C |
| 12 | Sun 7 Nov 2021 | 320-0 v Go Ahead EaglesAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Sun 21 Nov 2021 | 325-0 v RKC WaalwijkRKC Waalwijk 0-5 Ajax | Dutch Eredivisie |
| 14 | Sun 28 Nov 2021 | 321-0 v Sparta RotterdamSparta Rotterdam 0-1 Ajax | Dutch Eredivisie |
| 15 | Thu 2 Dec 2021 | 325-0 v Willem IIAjax 5-0 Willem II | Dutch Eredivisie |
| 16 | Tue 7 Dec 2021 | 324-2 v Sporting LisbonAjax 4-2 Sporting Lisbon | UEFA Champions League Group C |
| 17 | Sun 12 Dec 2021 | 321-2 v AZ AlkmaarAjax 1-2 AZ Alkmaar | Dutch Eredivisie |
| 18 | Sun 19 Dec 2021 | 322-0 v FeyenoordFeyenoord 0-2 Ajax | Dutch Eredivisie |
| 19 | Wed 22 Dec 2021 | 325-0 v Fortuna SittardAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
| 20 | Sun 16 Jan 2022 | 323-0 v FC UtrechtFC Utrecht 0-3 Ajax | Dutch Eredivisie |
| 21 | Sun 23 Jan 2022 | 322-1 v PSV EindhovenPSV Eindhoven 1-2 Ajax | Dutch Eredivisie |
| 22 | Sun 6 Feb 2022 | 323-0 v Heracles AlmeloAjax 3-0 Heracles Almelo | Dutch Eredivisie |
| 23 | Sun 13 Feb 2022 | 325-0 v FC TwenteAjax 5-0 FC Twente | Dutch Eredivisie |
| 24 | Sat 19 Feb 2022 | 321-0 v Willem IIWillem II 0-1 Ajax | Dutch Eredivisie |
| 25 | Wed 23 Feb 2022 | 322-2 v BenficaBenfica 2-2 Ajax | UEFA Champions League Round of 16 |
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