| 1 | Fri 27 Aug 2021 | 82-2 v RKC WaalwijkFortuna Sittard 2-2 RKC Waalwijk | Dutch Eredivisie |
| 2 | Sun 12 Sep 2021 | 8 1-3 v Sparta RotterdamSparta Rotterdam 3-1 Fortuna Sittard | Dutch Eredivisie |
| 3 | Fri 22 Oct 2021 | 81-1 v Willem IIWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 4 | Sun 31 Oct 2021 | 83-4 v Go Ahead EaglesGo Ahead Eagles 4-3 Fortuna Sittard | Dutch Eredivisie |
| 5 | Sun 7 Nov 2021 | 81-4 v PSV EindhovenFortuna Sittard 1-4 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sat 20 Nov 2021 | 8 1-3 v Heracles AlmeloHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 7 | Sat 27 Nov 2021 | 81-4 v FC GroningenFortuna Sittard 1-4 FC Groningen | Dutch Eredivisie |
| 8 | Thu 2 Dec 2021 | 81-2 v AZ AlkmaarAZ Alkmaar 2-1 Fortuna Sittard | Dutch Eredivisie |
| 9 | Sun 5 Dec 2021 | 80-5 v FeyenoordFeyenoord 5-0 Fortuna Sittard | Dutch Eredivisie |
| 10 | Sat 11 Dec 2021 | 81-0 v PEC ZwollePEC Zwolle 0-1 Fortuna Sittard | Dutch Eredivisie |
| 11 | Sat 18 Dec 2021 | 82-2 v FC UtrechtFortuna Sittard 2-2 FC Utrecht | Dutch Eredivisie |
| 12 | Wed 22 Dec 2021 | 80-5 v AjaxAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
| 13 | Sun 16 Jan 2022 | 81-2 v AZ AlkmaarFortuna Sittard 1-2 AZ Alkmaar | Dutch Eredivisie |
| 14 | Sun 23 Jan 2022 | 81-2 v RKC WaalwijkRKC Waalwijk 2-1 Fortuna Sittard | Dutch Eredivisie |
| 15 | Sat 5 Feb 2022 | 82-0 v sc HeerenveenFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 16 | Sat 12 Feb 2022 | 81-0 v FC GroningenFC Groningen 0-1 Fortuna Sittard | Dutch Eredivisie |
| 17 | Sun 6 Mar 2022 | 8 0-1 v PEC ZwolleFortuna Sittard 0-1 PEC Zwolle | Dutch Eredivisie |
| 18 | Sun 13 Mar 2022 | 81-0 v Willem IIFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 19 | Sun 20 Mar 2022 | 80-5 v PSV EindhovenPSV Eindhoven 5-0 Fortuna Sittard | Dutch Eredivisie |
| 20 | Sun 3 Apr 2022 | 80-2 v Heracles AlmeloFortuna Sittard 0-2 Heracles Almelo | Dutch Eredivisie |
| 21 | Sat 9 Apr 2022 | 81-1 v FC UtrechtFC Utrecht 1-1 Fortuna Sittard | Dutch Eredivisie |
| 22 | Sat 16 Apr 2022 | 83-0 v Sparta RotterdamFortuna Sittard 3-0 Sparta Rotterdam | Dutch Eredivisie |
| 23 | Sun 24 Apr 2022 | 81-0 v Go Ahead EaglesFortuna Sittard 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 24 | Sun 1 May 2022 | 81-3 v FeyenoordFortuna Sittard 1-3 Feyenoord | Dutch Eredivisie |
| 25 | Sat 7 May 2022 | 8 2-1 v FC TwenteFC Twente 1-2 Fortuna Sittard | Dutch Eredivisie |
| 26 | Sun 15 May 2022 | 81-0 v NEC NijmegenNEC Nijmegen 0-1 Fortuna Sittard | Dutch Eredivisie |
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