| 1 | Sat 20 Nov 2021 | 71-0 v Sparta RotterdamSparta Rotterdam 0-1 FC Twente | Dutch Eredivisie |
| 2 | Sun 28 Nov 2021 | 70-0 v FeyenoordFC Twente 0-0 Feyenoord | Dutch Eredivisie |
| 3 | Sun 5 Dec 2021 | 72-1 v Go Ahead EaglesGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 4 | Sun 12 Dec 2021 | 72-1 v RKC WaalwijkFC Twente 2-1 RKC Waalwijk | Dutch Eredivisie |
| 5 | Sat 18 Dec 2021 | 73-1 v PEC ZwollePEC Zwolle 1-3 FC Twente | Dutch Eredivisie |
| 6 | Sat 22 Jan 2022 | 71-0 v Willem IIWillem II 0-1 FC Twente | Dutch Eredivisie |
| 7 | Sat 5 Feb 2022 | 73-0 v VitesseFC Twente 3-0 Vitesse | Dutch Eredivisie |
| 8 | Sun 13 Feb 2022 | 70-5 v AjaxAjax 5-0 FC Twente | Dutch Eredivisie |
| 9 | Sun 20 Feb 2022 | 72-2 v Go Ahead EaglesFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Fri 25 Feb 2022 | 72-1 v RKC WaalwijkRKC Waalwijk 1-2 FC Twente | Dutch Eredivisie |
| 11 | Sun 13 Mar 2022 | 71-0 v AZ AlkmaarAZ Alkmaar 0-1 FC Twente | Dutch Eredivisie |
| 12 | Sat 19 Mar 2022 | 71-0 v PEC ZwolleFC Twente 1-0 PEC Zwolle | Dutch Eredivisie |
| 13 | Sat 2 Apr 2022 | 73-3 v PSV EindhovenFC Twente 3-3 PSV Eindhoven | Dutch Eredivisie |
| 14 | Fri 22 Apr 2022 | 72-0 v Sparta RotterdamFC Twente 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 15 | Sat 30 Apr 2022 | 71-1 v Heracles AlmeloHeracles Almelo 1-1 FC Twente | Dutch Eredivisie |
| 16 | Sat 7 May 2022 | 7 1-2 v Fortuna SittardFC Twente 1-2 Fortuna Sittard | Dutch Eredivisie |
| 17 | Wed 11 May 2022 | 73-0 v FC GroningenFC Twente 3-0 FC Groningen | Dutch Eredivisie |
| 18 | Sun 15 May 2022 | 72-1 v FeyenoordFeyenoord 1-2 FC Twente | Dutch Eredivisie |
| 19 | Sun 5 Jun 2022 | 172-2 v SpainCzech Republic 2-2 Spain | UEFA Nations League League A Group 2 |
| 20 | Sun 12 Jun 2022 | 170-2 v SpainSpain 2-0 Czech Republic | UEFA Nations League League A Group 2 |
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