| 1 | Sat 14 Aug 2021 | 3 0-2 v PSV EindhovenHeracles Almelo 0-2 PSV Eindhoven | Dutch Eredivisie |
| 2 | Sat 21 Aug 2021 | 31-1 v Sparta RotterdamSparta Rotterdam 1-1 Heracles Almelo | Dutch Eredivisie |
| 3 | Sun 19 Sep 2021 | 3 3-2 v AZ AlkmaarHeracles Almelo 3-2 AZ Alkmaar | Dutch Eredivisie |
| 4 | Sun 26 Sep 2021 | 31-0 v RKC WaalwijkHeracles Almelo 1-0 RKC Waalwijk | Dutch Eredivisie |
| 5 | Sat 2 Oct 2021 | 33-2 v Willem IIHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 6 | Sat 16 Oct 2021 | 32-4 v Go Ahead EaglesGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 7 | Sat 23 Oct 2021 | 30-1 v PEC ZwollePEC Zwolle 1-0 Heracles Almelo | Dutch Eredivisie |
| 8 | Sat 30 Oct 2021 | 3 0-0 v AjaxHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 9 | Fri 5 Nov 2021 | 3 0-1 v FC TwenteFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 10 | Sun 28 Nov 2021 | 30-1 v FC UtrechtFC Utrecht 1-0 Heracles Almelo | Dutch Eredivisie |
| 11 | Wed 1 Dec 2021 | 3 1-2 v FeyenoordFeyenoord 2-1 Heracles Almelo | Dutch Eredivisie |
| 12 | Sat 4 Dec 2021 | 3 0-1 v sc HeerenveenHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
| 13 | Sun 12 Dec 2021 | 31-2 v VitesseVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 14 | Sat 18 Dec 2021 | 34-2 v FC GroningenHeracles Almelo 4-2 FC Groningen | Dutch Eredivisie |
| 15 | Sat 15 Jan 2022 | 3 0-0 v NEC NijmegenNEC Nijmegen 0-0 Heracles Almelo | Dutch Eredivisie |
| 16 | Sun 23 Jan 2022 | 31-1 v Go Ahead EaglesHeracles Almelo 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 17 | Sun 6 Feb 2022 | 30-3 v AjaxAjax 3-0 Heracles Almelo | Dutch Eredivisie |
| 18 | Fri 11 Feb 2022 | 3 1-0 v FC UtrechtHeracles Almelo 1-0 FC Utrecht | Dutch Eredivisie |
| 19 | Sat 26 Feb 2022 | 32-0 v PEC ZwolleHeracles Almelo 2-0 PEC Zwolle | Dutch Eredivisie |
| 20 | Sun 6 Mar 2022 | 31-3 v PSV EindhovenPSV Eindhoven 3-1 Heracles Almelo | Dutch Eredivisie |
| 21 | Sun 13 Mar 2022 | 3 0-0 v VitesseHeracles Almelo 0-0 Vitesse | Dutch Eredivisie |
| 22 | Sun 3 Apr 2022 | 32-0 v Fortuna SittardFortuna Sittard 0-2 Heracles Almelo | Dutch Eredivisie |
| 23 | Sun 10 Apr 2022 | 31-4 v FeyenoordHeracles Almelo 1-4 Feyenoord | Dutch Eredivisie |
| 24 | Sat 30 Apr 2022 | 31-1 v FC TwenteHeracles Almelo 1-1 FC Twente | Dutch Eredivisie |
| 25 | Sat 7 May 2022 | 30-2 v Willem IIWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
| 26 | Wed 11 May 2022 | 30-2 v RKC WaalwijkRKC Waalwijk 2-0 Heracles Almelo | Dutch Eredivisie |
| 27 | Sun 15 May 2022 | 31-3 v Sparta RotterdamHeracles Almelo 1-3 Sparta Rotterdam | Dutch Eredivisie |
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