| 1 | Fri 27 Aug 2021 | 232-2 v RKC WaalwijkFortuna Sittard 2-2 RKC Waalwijk | Dutch Eredivisie |
| 2 | Sun 12 Sep 2021 | 231-3 v Sparta RotterdamSparta Rotterdam 3-1 Fortuna Sittard | Dutch Eredivisie |
| 3 | Sat 18 Sep 2021 | 230-1 v sc Heerenveensc Heerenveen 1-0 Fortuna Sittard | Dutch Eredivisie |
| 4 | Tue 21 Sep 2021 | 230-5 v AjaxFortuna Sittard 0-5 Ajax | Dutch Eredivisie |
| 5 | Sat 25 Sep 2021 | 231-1 v VitesseVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 6 | Sat 2 Oct 2021 | 231-3 v NEC NijmegenFortuna Sittard 1-3 NEC Nijmegen | Dutch Eredivisie |
| 7 | Fri 22 Oct 2021 | 231-1 v Willem IIWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 8 | Sun 31 Oct 2021 | 233-4 v Go Ahead EaglesGo Ahead Eagles 4-3 Fortuna Sittard | Dutch Eredivisie |
| 9 | Sun 7 Nov 2021 | 231-4 v PSV EindhovenFortuna Sittard 1-4 PSV Eindhoven | Dutch Eredivisie |
| 10 | Sat 20 Nov 2021 | 23 1-3 v Heracles AlmeloHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 11 | Sat 27 Nov 2021 | 231-4 v FC GroningenFortuna Sittard 1-4 FC Groningen | Dutch Eredivisie |
| 12 | Thu 2 Dec 2021 | 231-2 v AZ AlkmaarAZ Alkmaar 2-1 Fortuna Sittard | Dutch Eredivisie |
| 13 | Sun 5 Dec 2021 | 230-5 v FeyenoordFeyenoord 5-0 Fortuna Sittard | Dutch Eredivisie |
| 14 | Sat 11 Dec 2021 | 231-0 v PEC ZwollePEC Zwolle 0-1 Fortuna Sittard | Dutch Eredivisie |
| 15 | Sat 18 Dec 2021 | 232-2 v FC UtrechtFortuna Sittard 2-2 FC Utrecht | Dutch Eredivisie |
| 16 | Wed 22 Dec 2021 | 230-5 v AjaxAjax 5-0 Fortuna Sittard | Dutch Eredivisie |
| 17 | Sun 16 Jan 2022 | 231-2 v AZ AlkmaarFortuna Sittard 1-2 AZ Alkmaar | Dutch Eredivisie |
| 18 | Sun 23 Jan 2022 | 23 1-2 v RKC WaalwijkRKC Waalwijk 2-1 Fortuna Sittard | Dutch Eredivisie |
| 19 | Sat 5 Feb 2022 | 23 2-0 v sc HeerenveenFortuna Sittard 2-0 sc Heerenveen | Dutch Eredivisie |
| 20 | Sat 12 Feb 2022 | 231-0 v FC GroningenFC Groningen 0-1 Fortuna Sittard | Dutch Eredivisie |
| 21 | Sun 6 Mar 2022 | 230-1 v PEC ZwolleFortuna Sittard 0-1 PEC Zwolle | Dutch Eredivisie |
| 22 | Sun 13 Mar 2022 | 231-0 v Willem IIFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 23 | Sun 20 Mar 2022 | 230-5 v PSV EindhovenPSV Eindhoven 5-0 Fortuna Sittard | Dutch Eredivisie |
| 24 | Sun 3 Apr 2022 | 230-2 v Heracles AlmeloFortuna Sittard 0-2 Heracles Almelo | Dutch Eredivisie |
| 25 | Sat 9 Apr 2022 | 231-1 v FC UtrechtFC Utrecht 1-1 Fortuna Sittard | Dutch Eredivisie |
| 26 | Wed 11 May 2022 | 231-2 v VitesseFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
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