| 1 | Fri 13 Aug 2021 | 10-1 v sc HeerenveenGo Ahead Eagles 0-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 10-2 v FeyenoordFeyenoord 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 12-0 v Sparta RotterdamGo Ahead Eagles 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 19 Sep 2021 | 11-0 v PEC ZwolleGo Ahead Eagles 1-0 PEC Zwolle | Dutch Eredivisie |
| 5 | Wed 22 Sep 2021 | 11-2 v PSV EindhovenGo Ahead Eagles 1-2 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sun 26 Sep 2021 | 1 0-5 v AZ AlkmaarAZ Alkmaar 5-0 Go Ahead Eagles | Dutch Eredivisie |
| 7 | Sat 2 Oct 2021 | 11-1 v RKC WaalwijkRKC Waalwijk 1-1 Go Ahead Eagles | Dutch Eredivisie |
| 8 | Sat 16 Oct 2021 | 14-2 v Heracles AlmeloGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 9 | Sun 24 Oct 2021 | 12-1 v VitesseVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Sun 31 Oct 2021 | 14-3 v Fortuna SittardGo Ahead Eagles 4-3 Fortuna Sittard | Dutch Eredivisie |
| 11 | Sun 7 Nov 2021 | 10-0 v AjaxAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 12 | Sun 21 Nov 2021 | 10-1 v FC GroningenGo Ahead Eagles 0-1 FC Groningen | Dutch Eredivisie |
| 13 | Sat 27 Nov 2021 | 11-0 v Willem IIWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 14 | Sun 5 Dec 2021 | 11-2 v FC TwenteGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 15 | Sat 11 Dec 2021 | 10-0 v FC UtrechtFC Utrecht 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 16 | Sun 19 Dec 2021 | 10-2 v NEC NijmegenGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 17 | Thu 23 Dec 2021 | 10-2 v PSV EindhovenPSV Eindhoven 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 18 | Sat 15 Jan 2022 | 10-2 v RKC WaalwijkGo Ahead Eagles 0-2 RKC Waalwijk | Dutch Eredivisie |
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