| 1 | Sun 15 Aug 2021 | 30-4 v FeyenoordWillem II 0-4 Feyenoord | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 33-0 v VitesseVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 31-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 30-0 v NEC NijmegenNEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 5 | Sat 18 Sep 2021 | 32-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 6 | Tue 21 Sep 2021 | 32-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 7 | Sat 25 Sep 2021 | 32-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 8 | Sun 6 Feb 2022 | 33-1 v RKC WaalwijkWillem II 3-1 RKC Waalwijk | Dutch Eredivisie |
| 9 | Sun 13 Feb 2022 | 30-1 v Sparta RotterdamSparta Rotterdam 1-0 Willem II | Dutch Eredivisie |
| 10 | Sat 26 Feb 2022 | 30-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 11 | Sat 5 Mar 2022 | 30-0 v sc HeerenveenWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 12 | Sun 13 Mar 2022 | 30-1 v Fortuna SittardFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 13 | Sun 20 Mar 2022 | 32-2 v AZ AlkmaarWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
| 14 | Sat 2 Apr 2022 | 30-2 v FeyenoordFeyenoord 2-0 Willem II | Dutch Eredivisie |
| 15 | Fri 8 Apr 2022 | 30-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 16 | Sun 24 Apr 2022 | 31-0 v VitesseWillem II 1-0 Vitesse | Dutch Eredivisie |
| 17 | Sat 7 May 2022 | 32-0 v Heracles AlmeloWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
| 18 | Sun 15 May 2022 | 33-0 v FC UtrechtWillem II 3-0 FC Utrecht | Dutch Eredivisie |
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