| 1 | Sun 22 Aug 2021 | 213-0 v VitesseVitesse 0-3 Willem II | Dutch Eredivisie |
| 2 | Sat 28 Aug 2021 | 211-0 v PEC ZwolleWillem II 1-0 PEC Zwolle | Dutch Eredivisie |
| 3 | Sat 18 Sep 2021 | 212-1 v FC GroningenWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 4 | Tue 21 Sep 2021 | 212-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 5 | Sat 25 Sep 2021 | 212-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sat 2 Oct 2021 | 21 2-3 v Heracles AlmeloHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 7 | Sun 17 Oct 2021 | 211-1 v FC TwenteFC Twente 1-1 Willem II | Dutch Eredivisie |
| 8 | Fri 22 Oct 2021 | 21 1-1 v Fortuna SittardWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 9 | Sun 31 Oct 2021 | 211-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 10 | Sat 6 Nov 2021 | 210-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 11 | Sun 21 Nov 2021 | 211-2 v sc Heerenveensc Heerenveen 2-1 Willem II | Dutch Eredivisie |
| 12 | Sat 27 Nov 2021 | 210-1 v Go Ahead EaglesWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Thu 2 Dec 2021 | 210-5 v AjaxAjax 5-0 Willem II | Dutch Eredivisie |
| 14 | Sat 18 Dec 2021 | 211-4 v AZ AlkmaarAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 15 | Wed 22 Dec 2021 | 210-1 v NEC NijmegenWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 16 | Fri 14 Jan 2022 | 210-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 17 | Sat 22 Jan 2022 | 210-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 18 | Sun 13 Feb 2022 | 21 0-1 v Sparta RotterdamSparta Rotterdam 1-0 Willem II | Dutch Eredivisie |
| 19 | Sat 19 Feb 2022 | 210-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 20 | Sat 26 Feb 2022 | 210-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 21 | Sat 5 Mar 2022 | 210-0 v sc HeerenveenWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 22 | Sun 13 Mar 2022 | 210-1 v Fortuna SittardFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 23 | Sun 20 Mar 2022 | 212-2 v AZ AlkmaarWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
| 24 | Sat 2 Apr 2022 | 210-2 v FeyenoordFeyenoord 2-0 Willem II | Dutch Eredivisie |
| 25 | Fri 8 Apr 2022 | 210-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 26 | Sun 24 Apr 2022 | 211-0 v VitesseWillem II 1-0 Vitesse | Dutch Eredivisie |
| 27 | Sun 1 May 2022 | 212-4 v PSV EindhovenPSV Eindhoven 4-2 Willem II | Dutch Eredivisie |
| 28 | Sat 7 May 2022 | 212-0 v Heracles AlmeloWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
| 29 | Sun 15 May 2022 | 213-0 v FC UtrechtWillem II 3-0 FC Utrecht | Dutch Eredivisie |
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