| 1 | Sun 12 Sep 2021 | 31-1 v sc HeerenveenFC Groningen 1-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sat 18 Sep 2021 | 3 1-2 v Willem IIWillem II 2-1 FC Groningen | Dutch Eredivisie |
| 3 | Wed 22 Sep 2021 | 30-1 v VitesseFC Groningen 0-1 Vitesse | Dutch Eredivisie |
| 4 | Fri 1 Oct 2021 | 3 1-1 v FC TwenteFC Groningen 1-1 FC Twente | Dutch Eredivisie |
| 5 | Sun 17 Oct 2021 | 31-1 v Sparta RotterdamSparta Rotterdam 1-1 FC Groningen | Dutch Eredivisie |
| 6 | Sun 24 Oct 2021 | 32-0 v AZ AlkmaarFC Groningen 2-0 AZ Alkmaar | Dutch Eredivisie |
| 7 | Sun 31 Oct 2021 | 30-3 v NEC NijmegenNEC Nijmegen 3-0 FC Groningen | Dutch Eredivisie |
| 8 | Sun 7 Nov 2021 | 3 1-1 v RKC WaalwijkFC Groningen 1-1 RKC Waalwijk | Dutch Eredivisie |
| 9 | Sun 21 Nov 2021 | 31-0 v Go Ahead EaglesGo Ahead Eagles 0-1 FC Groningen | Dutch Eredivisie |
| 10 | Sat 27 Nov 2021 | 34-1 v Fortuna SittardFortuna Sittard 1-4 FC Groningen | Dutch Eredivisie |
| 11 | Fri 3 Dec 2021 | 31-1 v PEC ZwolleFC Groningen 1-1 PEC Zwolle | Dutch Eredivisie |
| 12 | Sun 12 Dec 2021 | 31-1 v FeyenoordFC Groningen 1-1 Feyenoord | Dutch Eredivisie |
| 13 | Sat 18 Dec 2021 | 32-4 v Heracles AlmeloHeracles Almelo 4-2 FC Groningen | Dutch Eredivisie |
| 14 | Tue 21 Dec 2021 | 30-1 v AZ AlkmaarAZ Alkmaar 1-0 FC Groningen | Dutch Eredivisie |
| 15 | Sun 16 Jan 2022 | 30-1 v PSV EindhovenFC Groningen 0-1 PSV Eindhoven | Dutch Eredivisie |
| 16 | Sat 22 Jan 2022 | 33-1 v VitesseVitesse 1-3 FC Groningen | Dutch Eredivisie |
| 17 | Sun 6 Feb 2022 | 32-1 v Go Ahead EaglesFC Groningen 2-1 Go Ahead Eagles | Dutch Eredivisie |
| 18 | Sat 12 Feb 2022 | 30-1 v Fortuna SittardFC Groningen 0-1 Fortuna Sittard | Dutch Eredivisie |
| 19 | Sun 20 Feb 2022 | 3 1-1 v PEC ZwollePEC Zwolle 1-1 FC Groningen | Dutch Eredivisie |
| 20 | Sat 26 Feb 2022 | 31-0 v Willem IIFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 21 | Sat 5 Mar 2022 | 31-1 v FeyenoordFeyenoord 1-1 FC Groningen | Dutch Eredivisie |
| 22 | Sat 12 Mar 2022 | 34-3 v NEC NijmegenFC Groningen 4-3 NEC Nijmegen | Dutch Eredivisie |
| 23 | Sun 20 Mar 2022 | 33-1 v FC UtrechtFC Utrecht 1-3 FC Groningen | Dutch Eredivisie |
| 24 | Sat 2 Apr 2022 | 31-3 v AjaxFC Groningen 1-3 Ajax | Dutch Eredivisie |
| 25 | Sun 10 Apr 2022 | 31-3 v sc Heerenveensc Heerenveen 3-1 FC Groningen | Dutch Eredivisie |
| 26 | Sun 24 Apr 2022 | 30-1 v Heracles AlmeloFC Groningen 0-1 Heracles Almelo | Dutch Eredivisie |
| 27 | Sun 1 May 2022 | 31-3 v RKC WaalwijkRKC Waalwijk 3-1 FC Groningen | Dutch Eredivisie |
| 28 | Sat 7 May 2022 | 31-2 v Sparta RotterdamFC Groningen 1-2 Sparta Rotterdam | Dutch Eredivisie |
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