| 1 | Sun 15 Aug 2021 | 5 0-4 v FeyenoordWillem II 0-4 Feyenoord | Dutch Eredivisie |
| 2 | Sun 12 Sep 2021 | 50-0 v NEC NijmegenNEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 3 | Tue 21 Sep 2021 | 52-1 v RKC WaalwijkRKC Waalwijk 1-2 Willem II | Dutch Eredivisie |
| 4 | Sat 25 Sep 2021 | 52-1 v PSV EindhovenWillem II 2-1 PSV Eindhoven | Dutch Eredivisie |
| 5 | Sat 2 Oct 2021 | 52-3 v Heracles AlmeloHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 6 | Sun 17 Oct 2021 | 51-1 v FC TwenteFC Twente 1-1 Willem II | Dutch Eredivisie |
| 7 | Fri 22 Oct 2021 | 51-1 v Fortuna SittardWillem II 1-1 Fortuna Sittard | Dutch Eredivisie |
| 8 | Sun 31 Oct 2021 | 51-5 v FC UtrechtFC Utrecht 5-1 Willem II | Dutch Eredivisie |
| 9 | Sat 6 Nov 2021 | 50-3 v Sparta RotterdamWillem II 0-3 Sparta Rotterdam | Dutch Eredivisie |
| 10 | Fri 14 Jan 2022 | 50-2 v PEC ZwollePEC Zwolle 2-0 Willem II | Dutch Eredivisie |
| 11 | Sat 22 Jan 2022 | 50-1 v FC TwenteWillem II 0-1 FC Twente | Dutch Eredivisie |
| 12 | Sat 19 Feb 2022 | 50-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 13 | Sun 20 Mar 2022 | 52-2 v AZ AlkmaarWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
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